Molecular structure of 6-Propyl-2-thiouracil, CAS Number: 51-52-5
6-Propyl-2-thiouracil (CAS 51-52-5)
Application:
6-Propyl-2-thiouracil is an inhibitor of DIO1
CAS Number:
51-52-5
Purity:
≥97%
Molecular Weight:
170.23
Molecular Formula:
C7H10N2OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
6-Propyl-2-thiouracil is a compound that functions as a thyrostatic agent by inhibiting the synthesis of thyroid hormones. It achieves this by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin, which is a step in the production of thyroid hormones. 6-Propyl-2-Thiouracil′s mechanism of action involves the inhibition of the enzyme thyroid peroxidase, which is responsible for catalyzing the iodination of tyrosine residues in thyroglobulin. By disrupting this process, 6-Propyl-2-thiouracil effectively reduces the production of thyroid hormones, ultimately leading to its thyrostatic activity. At the molecular level, 6-Propyl-2-thiouracil acts as a competitive inhibitor of the binding of iodide to the enzyme, thereby impeding the formation of thyroid hormones. In a development setting, 6-Propyl-2-thiouracil′s function lies in its ability to modulate thyroid hormone levels, making it useful for investigating thyroid physiology and related pathways.
6-Propyl-2-thiouracil (CAS 51-52-5) References
- Characterization of recombinant Xenopus laevis type I iodothyronine deiodinase: substitution of a proline residue in the catalytic center by serine (Pro132Ser) restores sensitivity to 6-propyl-2-thiouracil. | Kuiper, GG., et al. 2006. Endocrinology. 147: 3519-29. PMID: 16601143
- Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos. | Liu, C., et al. 2012. Aquat Toxicol. 118-119: 108-115. PMID: 22542736
- Protection against radiation-induced damage of 6-propyl-2-thiouracil (PTU) in thyroid cells. | Perona, M., et al. 2013. Radiat Res. 179: 352-60. PMID: 23398355
- Expression alterations of genes on both neuronal and glial development in rats after developmental exposure to 6-propyl-2-thiouracil. | Shiraki, A., et al. 2014. Toxicol Lett. 228: 225-34. PMID: 24780913
- Neonatal Persistent Exposure to 6-Propyl-2-thiouracil, a Thyroid-Disrupting Chemical, Differentially Modulates Expression of Hepatic Catalase and C/EBP-β in Adult Rats. | Bunker, SK., et al. 2016. J Biochem Mol Toxicol. 30: 80-90. PMID: 26459835
- 6-Propyl-2-thiouracil versus 6-methoxymethyl-2-thiouracil: enhancing the hydrogen-bonded synthon motif by replacement of a methylene group with an O atom. | Hützler, WM., et al. 2016. Acta Crystallogr C Struct Chem. 72: 634-46. PMID: 27487338
- Immunohistochemistry of aberrant neuronal development induced by 6-propyl-2-thiouracil in rats. | Shiraki, A., et al. 2016. Toxicol Lett. 261: 59-71. PMID: 27553673
- Cooked common bean flour, but not its protein hydrolysate, has the potential to improve gut microbiota composition and function in BALB/c mice fed a high-fat diet added with 6-propyl-2-thiouracil. | Gomes, MJC., et al. 2022. J Nutr Biochem. 106: 109022. PMID: 35483520
- Adverse effects of thyroid-hormone-disrupting chemicals 6-propyl-2-thiouracil and tetrabromobisphenol A on Japanese medaka (Oryzias latipes). | Horie, Y., et al. 2023. Comp Biochem Physiol C Toxicol Pharmacol. 263: 109502. PMID: 36368510
- Rational Coformer Selection in the Development of 6-Propyl-2-thiouracil Pharmaceutical Cocrystals. | Acebedo-Martínez, FJ., et al. 2023. Pharmaceuticals (Basel). 16: PMID: 36986470
- A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil. | Wilhelmi, P., et al. 2023. Chem Biol Interact. 382: 110565. PMID: 37236578
- Potentiometric and coulometric titration of 6-propyl-2-thiouracil. | Ciesielski, W. and Zakrzewski, R. 1997. Analyst. 122: 491-4. PMID: 9246819
- Effect of antithyroid agents 6-propyl-2-thiouracil and 1-mehtyl-2-mercaptoimidazole on human thyroid iodine peroxidase. | Nagasaka, A. and Hidaka, H. 1976. J Clin Endocrinol Metab. 43: 152-8. PMID: 947933
Inhibitor of:
μ-crystallin, c-Erb-A α, c-Erb-A α-1, c-Erb-A β-1, CYP2J11, DEHAL1, DIO1, DIO2, FOXE2, Fumarylacetoacetase, GCH-I, GPx-3, Halotyrosine, Iodothyronine deiodinase (DIO), MG50, OG1, OG2, ORG, peroxidase, SEP15, Spot 14, T2R06, T2R09, T2R13, T2R24, T2R42, T2R48, T2R9, thyroid peroxidase, Thyroperoxidase, Thyroxine, TRα, TRβ1, Triiodothyronine, TSHβ, and TSHR.Activator of:
DIO1, Olfr720, Pax-8, PBF, T2R04, T2R05, T2R06, T2R09, T2R10, T2R13, T2R134, T2R14, T2R15, T2R16, T2R17, T2R18, T2R20, T2R21, T2R22, T2R23, T2R24, T2R31, T2R37, T2R39, T2R4, T2R40, T2R41, T2R42, T2R43, T2R44, T2R45, T2R46, T2R47, T2R48, T2R49, T2R6, T2R7, T2R8, T2R9, Tas2r102, Tas2r103, Tas2r114, Tas2r125, Tas2r140, Tas2r143, TBG, Thyroglobulin, and Thyroxine.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-Propyl-2-thiouracil, 10 g | sc-214383 | 10 g | $37.00 | |||
6-Propyl-2-thiouracil, 25 g | sc-214383A | 25 g | $56.00 | |||
6-Propyl-2-thiouracil, 100 g | sc-214383B | 100 g | $224.00 | |||
6-Propyl-2-thiouracil, 1 kg | sc-214383C | 1 kg | $1997.00 |