6′-N-(Benzyloxycarbonyl)kanamycin A (CAS 40372-09-6)

6′-N-(Benzyloxycarbonyl)kanamycin A is a chemically modified derivative of kanamycin A, a naturally occurring aminoglycoside antibiotic, adapted for specific non-medical research applications in the field of biochemistry and molecular biology. This derivative is particularly enhanced by the introduction of a benzyloxycarbonyl (Cbz or Z) group, a common protecting group used in peptide synthesis. The Cbz group is attached to the amino group at the 6′ position of the kanamycin A molecule, which modifies its interaction with proteins and nucleic acids, thereby making it an excellent tool for studying the mechanism of action of aminoglycosides at the molecular level without the interference of its antibiotic activity. Researchers utilize this compound to explore the binding efficiencies and site-specific interactions of aminoglycosides with ribosomal RNA, which is crucial for understanding the fundamental processes of protein synthesis. Furthermore, 6′-N-(Benzyloxycarbonyl)kanamycin A serves as a pivotal molecule in the study of resistance mechanisms, helping to delineate how modifications in antibiotic structure can influence binding to mutated or modified biomolecular targets. Through these studies, it aids in the broader understanding of molecular recognition and binding specificity in the context of ribosomal function and nucleic acid chemistry.