Date published: 2026-4-19

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6-Phosphonohexanoic acid (CAS 5662-75-9)

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Alternate Names:
PHA
CAS Number:
5662-75-9
Purity:
97%
Molecular Weight:
196.14
Molecular Formula:
C6H13O5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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6-Phosphonohexanoic acid, an alkylphosphonic acid, possesses the remarkable ability to form a self-assembled monolayer on various surfaces. This compound features carboxylic groups that facilitate the grafting of surface atoms, while the phosphonic groups allow for surface modification of the substrate material. In vitro studies show that 6-Phosphonohexanoic acid induces apoptosis by inhibiting the release of interleukin-2 and other cytokines, which are involved in regulating immune responses. Additionally, 6-Phosphonohexanoic acid exhibits inhibitory effects on the formation of disulfide bonds, covalent bonds between sulfur atoms, as well as amide bonds formed between nitrogen atoms. Functionalized 6-Phosphonohexanoic acid demonstrates a higher formation rate compared to free 6-Phosphonohexanoic acid and exhibits enhanced stability in solution.


6-Phosphonohexanoic acid (CAS 5662-75-9) References

  1. Molecular discrimination of type-I over type-II methionyl aminopeptidases.  |  Swierczek, K., et al. 2005. Biochemistry. 44: 12049-56. PMID: 16142902
  2. The lathyrus toxin, beta-N-oxalyl-L-alpha,beta-diaminopropionic acid (ODAP), and homocysteic acid sensitize CA1 pyramidal neurons to cystine and L-2-amino-6-phosphonohexanoic acid.  |  Chase, LA., et al. 2007. Toxicol Appl Pharmacol. 219: 1-9. PMID: 17234231
  3. Label-free, electrical detection of the SARS virus N-protein with nanowire biosensors utilizing antibody mimics as capture probes.  |  Ishikawa, FN., et al. 2009. ACS Nano. 3: 1219-24. PMID: 19422193
  4. Efficient functionalization of magnetite nanoparticles with phosphonate using a one-step continuous hydrothermal process.  |  Thomas, G., et al. 2016. Dalton Trans. 45: 10821-9. PMID: 27295502
  5. Hydrogen-Bonded Liquid Crystal Nanocomposites.  |  Roohnikan, M., et al. 2016. Langmuir. 32: 8442-50. PMID: 27466705
  6. An impedimetric immunosensor for highly sensitive detection of IL-8 in human serum and saliva samples: A new surface modification method by 6-phosphonohexanoic acid for biosensing applications.  |  Aydın, EB. and Sezgintürk, MK. 2018. Anal Biochem. 554: 44-52. PMID: 29902421
  7. Screening and identification of a six-cytokine biosignature for detecting TB infection and discriminating active from latent TB.  |  Wang, S., et al. 2018. J Transl Med. 16: 206. PMID: 30029650
  8. A disposable and ultrasensitive ITO based biosensor modified by 6-phosphonohexanoic acid for electrochemical sensing of IL-1β in human serum and saliva.  |  Aydın, EB. and Sezgintürk, MK. 2018. Anal Chim Acta. 1039: 41-50. PMID: 30322551
  9. Smart Supramolecular Self-Assembled Nanosystem: Stimulus-Responsive Hydrogen-Bonded Liquid Crystals.  |  Liu, B., et al. 2021. Nanomaterials (Basel). 11: PMID: 33578814
  10. Substrate Materials for Biomolecular Immobilization within Electrochemical Biosensors.  |  Suni, II. 2021. Biosensors (Basel). 11: PMID: 34356710
  11. Towards Fully Integrated Portable Sensing Devices for COVID-19 and Future Global Hazards: Recent Advances, Challenges, and Prospects.  |  Shaffaf, T., et al. 2021. Micromachines (Basel). 12: PMID: 34442537
  12. Malignancies and Biosensors: A Focus on Oral Cancer Detection through Salivary Biomarkers.  |  Goldoni, R., et al. 2021. Biosensors (Basel). 11: PMID: 34677352
  13. Synthesis of oxadiazolidinedione derivatives as quisqualic acid analogues and their evaluation at a quisqualate-sensitized site in the rat hippocampus.  |  Venkatraman, S., et al. 1994. J Med Chem. 37: 3939-46. PMID: 7966155

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

6-Phosphonohexanoic acid, 1 g

sc-233643
1 g
$84.00