6-(N-Trifluoroacetyl)caproic acid NHS (CAS 117032-51-6)
Alternate Names:
TFCS; 6-(N-Trifluoroacetyl)CAP; N-(ε-trifluoroacetylcaproyloxy)-N-hydroxysuccinimide ester
Application:
6-(N-Trifluoroacetyl)caproic acid NHS is used to temporarily block amine groups in target molecules and to extend lysine side chains to reduce steric hindrance
CAS Number:
117032-51-6
Purity:
≥98%
Molecular Weight:
324.25
Molecular Formula:
C12H15F3N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
6-(N-Trifluoroacetyl)caproic acid NHS, also known as TCFS, is an amine-reactive modification reagent with a protected primary amine group. It forms amide bonds with primary amines (e.g., lysine side chains) to add a seven-atom spacer arm (7.7 angstroms) terminated by a trifluoroacetyl group that can be removed later to expose a new primary amine. Its benefits lie in its ability to add a protected primary amine group, extend lysine side-chain length to alter steric hindrance and block amine groups and replace them with one on a 7-atom spacer. The leaving group is readily removed unmasking a primary amine capable of reacting with any amine-reactive crosslinker.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-(N-Trifluoroacetyl)caproic acid NHS, 250 mg | sc-478829 | 250 mg | $290.00 |