Molecular structure of 6-Methylpurine, CAS Number: 2004-03-7
6-Methylpurine (CAS 2004-03-7)
CAS Number:
2004-03-7
Molecular Weight:
134.14
Molecular Formula:
C6H6N4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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6-Methylpurine, a purine nucleoside analogue, has been employed to investigate the biochemical and physiological impacts of purines and their derivatives, as well as to explore the underlying biological mechanisms of these compounds. Acting as an antagonist, 6-Methylpurine binds to and blocks the activation of the purine receptor, a G-protein coupled receptor in numerous physiological processes. This interaction hinders the initiation of downstream signaling pathways associated with the receptor′s activation.
6-Methylpurine (CAS 2004-03-7) References
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- A long-acting suicide gene toxin, 6-methylpurine, inhibits slow growing tumors after a single administration. | Gadi, VK., et al. 2003. J Pharmacol Exp Ther. 304: 1280-4. PMID: 12604707
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- Synergistic antitumor efficacy of suicide/ePNP gene and 6-methylpurine 2'-deoxyriboside via Salmonella against murine tumors. | Fu, W., et al. 2008. Cancer Gene Ther. 15: 474-84. PMID: 18437183
- Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy. | Lubin, M. and Lubin, A. 2009. PLoS One. 4: e5735. PMID: 19478948
- Incorporation of label from radioactive uridine into the stylar nucleic acids of Lilium longiflorum thunb. as affected by heat, 6-methylpurine and actinomycin D. | Campbell, RJ. and Ascher, PD. 1976. Theor Appl Genet. 47: 215-26. PMID: 24414758
- A comparative study on FT-IR, conformational and electronic structure of 6-methylpurine. | Sahebalzamani, H. 2014. Spectrochim Acta A Mol Biomol Spectrosc. 128: 559-66. PMID: 24691370
- Development of an Effective 6-Methylpurine Counterselection Marker for Genetic Manipulation in Thermococcus barophilus. | Birien, T., et al. 2018. Genes (Basel). 9: PMID: 29414865
- Resistance to 6-Methylpurine is Conferred by Defective Adenine Phosphoribosyltransferase in Tetrahymena. | Akematsu, T., et al. 2018. Genes (Basel). 9: PMID: 29570682
- 6-Methylpurine, 6-methyl-9-beta-D-ribofuranosylpurine, and 6-hydroxymethyl-9-beta-D-ribofuranosylpurine as antiviral metabolites of Collybia maculata (Basidiomycetes). | Leonhardt, K., et al. 1987. Z Naturforsch C J Biosci. 42: 420-4. PMID: 3037810
- Synthesis of 9-(6-Deoxy-α-L-Talofuranosyl)-6-Methylpurine and 9-(6-Deoxy-β-D-Allofuranosyl)-6-Methylpurine Nucleosides. | Hassan, AEA., et al. 2020. Curr Protoc Nucleic Acid Chem. 81: e105. PMID: 32255553
- Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient-derived xenografts. | Rab, R., et al. 2023. Cancer Rep (Hoboken). 6: e1708. PMID: 36253876
- Inhibition of de novo purine biosynthesis and interconversion by 6-methylpurine in Escherichia coli. | Benson, CE., et al. 1970. J Bacteriol. 101: 872-80. PMID: 4908785
- Induced resistance to 6-methylpurine and cycloheximide in tetrahymena. I. Germ line mutants of T. thermophila. | Byrne, BC., et al. 1978. Genetics. 89: 695-702. PMID: 689366
- Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells. | Parker, WB., et al. 1998. Biochem Pharmacol. 55: 1673-81. PMID: 9634004
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PNP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-Methylpurine, 100 mg | sc-207123 | 100 mg | $67.00 | |||
6-Methylpurine, 250 mg | sc-207123A | 250 mg | $116.00 |