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6-Methylpterin (CAS 708-75-8)

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Alternate Names:
2-Amino-6-methyl-4(3H)-pteridinone; 2-Amino-4-hydroxy-6-methylpteridine
CAS Number:
708-75-8
Molecular Weight:
177.16
Molecular Formula:
C7H7N5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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6-Methylpterin is an organic compound that belongs to the family of pteridinones, a class of nitrogen-containing heterocyclic compounds. 6-Methylpterin has the ability to scavenge free radicals, reduce lipid peroxidation, and inhibit the production of pro-inflammatory cytokines. In the realm of biochemistry and molecular biology, 6-methylpterin is of interest for its potential involvement in and impact on the metabolic pathways associated with pterins and folates. Pterins themselves are integral to the structure of several important cofactors, such as tetrahydrobiopterin (BH4), which is involved in the hydroxylation of aromatic amino acids and the synthesis of neurotransmitters like dopamine and serotonin. While 6-methylpterin doesn′t directly participate in these biological processes, its presence and behavior can provide insight into the metabolic fate and biological roles of methylated pterins.


6-Methylpterin (CAS 708-75-8) References

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  2. Determination of methylglyoxal in ruminal fluid by high-performance liquid chromatography using fluorometric detection.  |  Lodge-Ivey, SL., et al. 2004. J Agric Food Chem. 52: 6875-8. PMID: 15537289
  3. Photochemical behavior of 6-methylpterin in aqueous solutions: generation of reactive oxygen species.  |  Cabrerizo, FM., et al. 2005. Photochem Photobiol. 81: 793-801. PMID: 15720158
  4. Substituent effects on the photophysical properties of pterin derivatives in acidic and alkaline aqueous solutions.  |  Cabrerizo, FM., et al. 2005. Photochem Photobiol. 81: 1234-40. PMID: 16225380
  5. Reactivity of conjugated and unconjugated pterins with singlet oxygen (O2(1Deltag)): physical quenching and chemical reaction.  |  Cabrerizo, FM., et al. 2007. Photochem Photobiol. 83: 526-34. PMID: 17076587
  6. Quenching of the fluorescence of aromatic pterins by deoxynucleotides.  |  Petroselli, G., et al. 2009. J Phys Chem A. 113: 1794-9. PMID: 19199487
  7. Electron-transfer processes induced by the triplet state of pterins in aqueous solutions.  |  Dántola, ML., et al. 2010. Free Radic Biol Med. 49: 1014-22. PMID: 20600840
  8. Mechanism of photooxidation of folic acid sensitized by unconjugated pterins.  |  Dántola, ML., et al. 2010. Photochem Photobiol Sci. 9: 1604-12. PMID: 20922252
  9. A simple HPLC-ESI-MS method for the direct determination of ten pteridinic biomarkers in human urine.  |  Jiménez Girón, A., et al. 2012. Talanta. 101: 465-72. PMID: 23158350
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  11. How Is the Oxidation Related to the Tautomerization in Vitamin B9?  |  Yamabe, S., et al. 2021. J Phys Chem A. 125: 9346-9354. PMID: 34663066
  12. Identification of a pterin as the acrasin of the cellular slime mold Dictyostelium lacteum.  |  Van Haastert, PJ., et al. 1982. Proc Natl Acad Sci U S A. 79: 6270-4. PMID: 6959117
  13. Separation of unconjugated pteridines by high-pressure cation-exchange liquid chromatography.  |  Stea, B., et al. 1979. J Chromatogr. 168: 385-93. PMID: 762233
  14. High-performance liquid chromatographic-fluorometric determination of glyoxal, methylglyoxal, and diacetyl in urine by prederivatization to pteridinic rings.  |  Espinosa-Mansilla, A., et al. 1998. Anal Biochem. 255: 263-73. PMID: 9451513

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

6-Methylpterin, 250 mg

sc-498046
250 mg
$380.00