6-Methylmercaptopurine-d3 (CAS 33312-93-5)
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6-Methylmercaptopurine-d3 is a labeled analog of 6-methylmercaptopurine, an organosulfur compound that′s employed in various research applications, particularly in the field of chemistry. Chemists use this isotopically labeled version to investigate the metabolic pathways of thiopurine compounds, leveraging the deuterium atoms to trace the molecular transformations within chemical systems. It is also useful in the study of the mechanisms of action and inactivation of sulfur-containing heterocyclic molecules. In addition, 6-Methylmercaptopurine-d3 is used in environmental studies to understand the degradation and persistence of related compounds in ecosystems. The isotopic labeling of this compound enhances the sensitivity of detection methods such as mass spectrometry, making it a useful standard for quantifying the presence of thiopurines in complex mixtures.
6-Methylmercaptopurine-d3 (CAS 33312-93-5) References
- Analytical and clinical validation of an LC-MS/MS method to measure thiopurine S-methyltransferase activity by quantifying d3-6-MMP. | Ma, J., et al. 2018. Clin Biochem. 54: 100-105. PMID: 29425801
- Simultaneous UPLC-MS/MS Determination of 6-mercaptopurine, 6-methylmercaptopurine and 6-thioguanine in Plasma: Application to the Pharmacokinetic Evaluation of Novel Dosage forms in Beagle Dogs. | Han, J., et al. 2020. Curr Pharm Des. 26: 6013-6020. PMID: 32867649
- NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells. | Somazu, S., et al. 2021. J Cell Mol Med. 25: 10521-10533. PMID: 34636169
- Analysis of mono-, di-, and triphosphates of thioguanosine and methylthioinosine in children with acute lymphoblastic leukemia by LC-MS/MS. | Han, J., et al. 2022. J Pharm Biomed Anal. 217: 114813. PMID: 35550492
- CRISPR/Cas9-Mediated Induction of Relapse-Specific NT5C2 and PRPS1 Mutations Confers Thiopurine Resistance as a Relapsed Lymphoid Leukemia Model. | Nguyen, TTT., et al. 2023. Mol Pharmacol. 103: 199-210. PMID: 36669880
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-Methylmercaptopurine-d3, 2.5 mg | sc-482989 | 2.5 mg | $393.00 |