Molecular structure of 6-Ketocholestanol, CAS Number: 1175-06-0
6-Ketocholestanol (CAS 1175-06-0)
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Alternate Names:
5α-Cholestan-6-one; 6-Oxocholestanol; 3β-Hydroxy-5α-cholestan-6-one
Application:
6-Ketocholestanol is an oxygenated cholesterol compound
CAS Number:
1175-06-0
Purity:
≥95%
Molecular Weight:
402.65
Molecular Formula:
C27H46O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
6-Ketocholestanol is a compound produced by the oxidation of the 6-hydroxyl group of cholesterol. This derivative of cholesterol is believed to function as an antioxidant by neutralizing reactive oxygen species. Additionally, it has been demonstrated to impede the function of enzymes that are responsible for generating reactive oxygen species.
6-Ketocholestanol (CAS 1175-06-0) References
- Influence of phloretin and 6-ketocholestanol on the permeation of progesterone through porcine skin. | Valenta, C., et al. 2001. Int J Pharm. 217: 79-86. PMID: 11292544
- Influence of lipophilic counter-ions in combination with phloretin and 6-ketocholestanol on the skin permeation of 5-aminolevulinic acid. | Auner, BG., et al. 2003. Int J Pharm. 255: 109-16. PMID: 12672607
- Influence of phloretin and 6-ketocholestanol on the skin permeation of sodium-fluorescein. | Auner, BG., et al. 2003. J Control Release. 89: 321-8. PMID: 12711454
- Phloretin and 6-ketocholestanol: membrane interactions studied by a phospholipid/polydiacetylene colorimetric assay and differential scanning calorimetry. | Valenta, C., et al. 2004. Eur J Pharm Biopharm. 57: 329-36. PMID: 15018992
- Influence of 6-ketocholestanol on skin permeation of 5-aminolevulinic acid and evaluation of chemical stability. | Auner, BG., et al. 2004. J Pharm Sci. 93: 2780-7. PMID: 15378565
- Interaction of phloretin and 6-ketocholestanol with DPPC-liposomes as phospholipid model membranes. | Auner, BG., et al. 2005. Int J Pharm. 294: 149-55. PMID: 15814239
- The alteration of lipid bilayer dynamics by phloretin and 6-ketocholestanol. | Przybylo, M., et al. 2014. Chem Phys Lipids. 178: 38-44. PMID: 24316311
- Effect of Cholesterol and 6-Ketocholestanol on Membrane Dipole Potential and Sterol Flip-Flop Motion in Bilayer Membranes. | Shen, H., et al. 2019. Langmuir. 35: 11232-11241. PMID: 31373497
- 6-Ketocholestanol suppresses lipid accumulation by decreasing FASN gene expression through SREBP-dependent regulation in HepG2 cells. | Shirouchi, B., et al. 2020. Cytotechnology. 72: 175-187. PMID: 31933103
- Inhibition of respiratory complex I by 6-ketocholestanol: Relevance to recoupling action in mitochondria. | Grivennikova, VG., et al. 2022. Biochim Biophys Acta Bioenerg. 1863: 148594. PMID: 35850263
- Effect of 6-ketocholestanol on FCCP- and DNP-induced uncoupling in plant mitochondria. | Vianello, A., et al. 1995. FEBS Lett. 365: 7-9. PMID: 7774718
- 6-ketocholestanol abolishes the effect of the most potent uncouplers of oxidative phosphorylation in mitochondria. | Starkov, AA., et al. 1994. FEBS Lett. 355: 305-8. PMID: 7988694
- 6-Ketocholestanol is a recoupler for mitochondria, chromatophores and cytochrome oxidase proteoliposomes. | Starkov, AA., et al. 1997. Biochim Biophys Acta. 1318: 159-72. PMID: 9030261
- Further studies on the recoupling effect of 6-ketocholestanol upon oxidative phosphorylation in uncoupled liver mitochondria. | Cuéllar, A., et al. 1997. FEBS Lett. 411: 365-8. PMID: 9271237
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-Ketocholestanol, 250 mg | sc-210525A | 250 mg | $208.00 | |||
6-Ketocholestanol, 2.5 g | sc-210525 | 2.5 g | $750.00 |