Molecular structure of 6-keto Prostaglandin E1, CAS Number: 67786-53-2
6-keto Prostaglandin E1 (CAS 67786-53-2)
Alternate Names:
6-Oxoprostaglandin E1; 6,9-dioxo-11R,15S-dihydroxy-13E-prostenoic acid
Application:
6-keto Prostaglandin E1 is a metabolite of PGI2
CAS Number:
67786-53-2
Molecular Weight:
368.46
Molecular Formula:
C20H32O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A metabolite isolated after the incubation of PGI2 with rabbit liver microsomes.1 Although, it is not produced in appreciable amounts following IV infusion of PGI2 in humans.2 It is equipotent with PGI2 as a vasodilator, while in most other aspects its activity resembles PGE1.3
6-keto Prostaglandin E1 (CAS 67786-53-2) References
- 6-Keto-prostaglandin E1 and the decidual cell reaction in rats. | Doktorcik, PE. and Kennedy, TG. 1986. Prostaglandins. 32: 679-89. PMID: 3469690
- Biological activities of 6-keto-prostaglandin E1. | Lewis, R., et al. 1984. Prostaglandins Leukot Med. 16: 303-24. PMID: 6098901
- A comparison of some pharmacological actions of prostaglandin E1, 6-oxo-PGE1 and PGI2. | Adaikan, PG., et al. 1984. Prostaglandins. 27: 505-16. PMID: 6203140
- Placental vascular responses to 6-keto-prostaglandin E1 in the near-term sheep. | Schwartz, DB., et al. 1983. Am J Obstet Gynecol. 145: 406-10. PMID: 6337494
- 6-Keto-prostaglandin E1: its formation by platelets from prostacyclin and resistance to pulmonary degradation. | Berry, CN. and Hoult, JR. 1983. Pharmacology. 26: 324-30. PMID: 6348806
- 6-Keto-prostaglandin E1-stimulated bone resorption in organ culture. | Dewhirst, FE. 1984. Calcif Tissue Int. 36: 380-3. PMID: 6435837
- Enzymatic inactivation of 6-keto-prostaglandin E1 in vitro: comparison with prostaglandin E1. | Berry, CN., et al. 1984. Biochem Pharmacol. 33: 1277-84. PMID: 6549614
- Hepatic metabolism of prostacyclin (PGI2) in the rabbit: formation of a potent novel inhibitor of platelet aggregation. | Wong, PY., et al. 1980. Biochem Biophys Res Commun. 93: 486-94. PMID: 6992772
- Assessment of the extent to exogenous prostaglandin I2 is converted to 6-keto-prostaglandin E1 in human subjects. | Jackson, EK., et al. 1982. J Pharmacol Exp Ther. 221: 183-7. PMID: 7038095
- Vasodilator actions of prostaglandin 6-keto-E1 in the pulmonary vascular bed. | Hyman, AL. and Kadowitz, PJ. 1980. J Pharmacol Exp Ther. 213: 468-72. PMID: 7193724
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-keto Prostaglandin E1, 1 mg | sc-205157 | 1 mg | $128.00 | |||
6-keto Prostaglandin E1, 5 mg | sc-205157A | 5 mg | $578.00 |