6-Hydroxyoxindole (CAS 6855-48-7)
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6-Hydroxyoxindole (6-HIO) is a versatile heterocyclic organic compound. Derived naturally from tryptophan, an essential amino acid abundantly present in various food sources, 6-Hydroxyoxindole also goes by the names indole-2-carboxaldehyde and indole-2-carboxylic acid. In scientific research, 6-Hydroxyoxindole finds widespread utility across a myriad of applications. It serves as a valuable chemical reagent, enabling the synthesis of diverse chemical compounds, including indole-3-carboxylic acid, indole-3-acetic acid, and indole-3-aldehyde. Furthermore, 6-Hydroxyoxindole acts as a significant biochemical marker, facilitating the identification of various metabolic pathways such as the kynurenine pathway. The precise mechanism of action underlying 6-Hydroxyoxindole′s effects remains incompletely elucidated. However, current understanding suggests its role as an inhibitor of the enzyme indoleamine 2,3-dioxygenase (IDO).
6-Hydroxyoxindole (CAS 6855-48-7) References
- Synthesis and evaluation of prodrugs for anti-angiogenic pyrrolylmethylidenyl oxindoles. | Maskell, L., et al. 2007. Bioorg Med Chem Lett. 17: 1575-8. PMID: 17254788
- The metabolism of [2-14C] indole in the rat. | King, LJ., et al. 1966. Biochem J. 98: 266-77. PMID: 5328168
- The metabolism of oxindole and related compounds. | Beckett, AH. and Morton, DM. 1966. Biochem Pharmacol. 15: 937-46. PMID: 5967904
- Identification of goat and mouse urinary metabolites of the pneumotoxin, 3-methylindole. | Smith, DJ., et al. 1993. Xenobiotica. 23: 1025-44. PMID: 8291262
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-Hydroxyoxindole, 250 mg | sc-278520 | 250 mg | $220.00 | |||
6-Hydroxyoxindole, 1 g | sc-278520A | 1 g | $520.00 |