Date published: 2026-4-24

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6-Hydroxydopamine hydrobromide (CAS 636-00-0)

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Alternate Names:
6-OHDA
Application:
6-Hydroxydopamine hydrobromide is an oxygen compound that destroys catecholaminergic terminals
CAS Number:
636-00-0
Purity:
95%
Molecular Weight:
250.09
Molecular Formula:
C8H11NO3•HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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6-Hydroxydopamine hydrobromide is a neurotoxin which destroys catecholaminergic terminals. 6-Hydroxydopamine hydrobromide is a synthetic compound widely utilized in scientific research due to its dual properties as a dopamine agonist and inhibitor. As a catecholamine metabolite and derivative of dopamine, it has undergone extensive investigation to elucidate its impact on dopaminergic neurons and unravel the intricate involvement of dopamine in diverse biological processes.


6-Hydroxydopamine hydrobromide (CAS 636-00-0) References

  1. Fibroblast growth factor-2-producing fibroblasts protect the nigrostriatal dopaminergic system from 6-hydroxydopamine.  |  Shults, CW., et al. 2000. Brain Res. 883: 192-204. PMID: 11074048
  2. Animal model of neuropathic tachycardia syndrome.  |  Carson, RP., et al. 2001. Hypertension. 37: 1357-61. PMID: 11408377
  3. Nicotine's attenuation of body weight involves the perifornical hypothalamus.  |  Kramer, PR., et al. 2007. Life Sci. 81: 500-8. PMID: 17655879
  4. Chronopharmacological study of furosemide; (V). Influence of pretreatment with 6-hydroxydopamine.  |  Fujimura, A. and Ebihara, A. 1990. Life Sci. 46: 827-31. PMID: 2108290
  5. Sympathetic Nervous System Control of Carbon Tetrachloride-Induced Oxidative Stress in Liver through α-Adrenergic Signaling.  |  Lin, JC., et al. 2016. Oxid Med Cell Longev. 2016: 3190617. PMID: 26798417
  6. Dopamine Modulates Motor Control in a Specific Plane Related to Support.  |  Herbin, M., et al. 2016. PLoS One. 11: e0155058. PMID: 27145032
  7. Sympathectomy reduces tumor weight and affects expression of tumor-related genes in melanoma tissue in the mouse.  |  Horvathova, L., et al. 2016. Stress. 19: 528-34. PMID: 27416924
  8. Alterations in beta-adrenoceptor number and catecholamine content of chick atria after reversible sympathetic denervation with 6-hydroxydopamine.  |  Williams, K., et al. 1987. Naunyn Schmiedebergs Arch Pharmacol. 336: 64-9. PMID: 2819747
  9. Sympathetic ablation alters lymphocyte membrane properties.  |  Miles, K., et al. 1985. J Immunol. 135: 797s-801s. PMID: 2861234
  10. Prolongation of absence seizures and changes in serotonergic and dopaminergic neurotransmission by nigrostriatal pathway degeneration in genetic absence epilepsy rats.  |  Tugba, EK., et al. 2022. Pharmacol Biochem Behav. 213: 173317. PMID: 34974062
  11. Exercise improves the body function and protects the neuronal injury in Parkinson's disease rats by activating calpain 1 and kallikrein 6.  |  Guo, J., et al. 2022. Folia Neuropathol. 60: 301-307. PMID: 36382482
  12. Characterizing the relationship between L-DOPA-induced-dyskinesia and psychosis-like behaviors in a bilateral rat model of Parkinson's disease.  |  Lipari, N., et al. 2023. Neurobiol Dis. 176: 105965. PMID: 36526089
  13. Long-lasting peripheral and central effects of 6-hydroxydopamine in rats.  |  Clark, DW., et al. 1972. Br J Pharmacol. 44: 233-43. PMID: 4677508
  14. Prepulse inhibition of the acoustic startle response of rats is reduced by 6-hydroxydopamine lesions of the medial prefrontal cortex.  |  Bubser, M. and Koch, M. 1994. Psychopharmacology (Berl). 113: 487-92. PMID: 7862864

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

6-Hydroxydopamine hydrobromide, 50 mg

sc-256988
50 mg
$94.00

6-Hydroxydopamine hydrobromide, 250 mg

sc-256988A
250 mg
$250.00

Hello Is this product (sc-256988A 250mg) in stock? Thanks Eden

Asked by: Eden
Thank you for your question. For stock and a pricing quote please email scbt@scbt.com.
Answered by: BlakeJ
Date published: 2024-08-12

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-256988, is provided as a brown solid. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-12
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Rated 3 out of 5 by from We used this chemical in mouse cells andWe used this chemical in mouse cells and the results were acceptable.
Date published: 2015-09-24
Rated 4 out of 5 by from Used in vivo with miceUsed in vivo with mice. Found tricky to work with, as it is sensitive to oxidation.
Date published: 2015-07-27
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6-Hydroxydopamine hydrobromide is rated 3.5 out of 5 by 2.
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