Date published: 2026-5-31

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6-Hydroxy buspirone (CAS 125481-61-0)

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Alternate Names:
6-Hydroxy-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9- dione
Application:
6-Hydroxy buspirone is a major active metabolite of Buspirone
CAS Number:
125481-61-0
Molecular Weight:
401.50
Molecular Formula:
C21H31N5O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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6-Hydroxy buspirone is a primary metabolite of buspirone that garners interest in research areas focusing on metabolic profiling and chemical kinetics. Utilizing 6-Hydroxy buspirone, scientists can investigate the metabolic pathways of buspirone, including the identification of specific enzymes responsible for its biotransformation. This metabolite is also significant in studies aimed at understanding the interaction between buspirone and its metabolites with biological targets. In addition, 6-Hydroxy buspirone plays a role in the development of analytical methods, serving as a reference standard in the quantification of buspirone metabolites in biological fluids. The research involving 6-Hydroxy buspirone helps in elucidating the chemical′s metabolism and elimination, providing insight into its mechanism of action.


6-Hydroxy buspirone (CAS 125481-61-0) References

  1. Psychological stress-induced enhancement of brain lipid peroxidation via nitric oxide systems and its modulation by anxiolytic and anxiogenic drugs in mice.  |  Matsumoto, K., et al. 1999. Brain Res. 839: 74-84. PMID: 10482801
  2. Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes.  |  Zhu, M., et al. 2005. Drug Metab Dispos. 33: 500-7. PMID: 15640381
  3. Enantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3.  |  Landwehr, M., et al. 2006. J Am Chem Soc. 128: 6058-9. PMID: 16669674
  4. 6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats.  |  Wong, H., et al. 2007. Drug Metab Dispos. 35: 1387-92. PMID: 17494642
  5. The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography-tandem mass spectrometric method of a specific probe buspirone.  |  Zhu, L., et al. 2013. Food Chem Toxicol. 51: 396-403. PMID: 23085095
  6. Mechanism of action of the SPARI vilazodone: serotonin 1A partial agonist and reuptake inhibitor.  |  Stahl, SM. 2014. CNS Spectr. 19: 105-9. PMID: 24673885
  7. The influences of aconitine, an active/toxic alkaloid from aconitum, on the oral pharmacokinetics of CYP3A probe drug buspirone in rats.  |  Zhu, L., et al. 2014. Drug Metab Lett. 8: 135-44. PMID: 25434398
  8. Differential regulation of intestinal and hepatic CYP3A by 1α,25-dihydroxyvitamin D3 : Effects on in vivo oral absorption and disposition of buspirone in rats.  |  Maeng, HJ., et al. 2019. Drug Dev Res. 80: 333-342. PMID: 30537097
  9. Interaction of buspirone and its major metabolites with human organic cation transporters.  |  Jinakote, M., et al. 2023. Fundam Clin Pharmacol.. PMID: 36843181

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

6-Hydroxy buspirone, 1 mg

sc-210515
1 mg
$305.00

6-Hydroxy buspirone, 1 mg

sc-210515-CW
1 mg
$468.00