Molecular structure of 6-Fluoromevalonate, CAS Number: 2822-77-7
6-Fluoromevalonate (CAS 2822-77-7)
Alternate Names:
ZR 3516
Application:
6-Fluoromevalonate is an inhibitor of MVD (mevalonate-pyrophosphate decarboxylase)
CAS Number:
2822-77-7
Purity:
≥90%
Molecular Weight:
148.13
Molecular Formula:
C6H9FO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Technical Information
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SDS & Certificate of Analysis
6-Fluoromevalonate, a chemical compound known for its potential applications in diverse fields, has garnered considerable attention within the scientific community. As a fluorinated analogue of mevalonate, a precursor to isoprenoid compounds, it holds significant value in scientific research. The compound finds utility in studying isoprenoid biosynthesis and protein prenylation. Isoprenoids encompass a wide array of compounds for numerous biological processes, including signal transduction, membrane structure, and hormone synthesis. By utilizing 6-Fluoromevalonate, researchers can explore the regulation of isoprenoid biosynthesis and observe the repercussions of isoprenoid depletion on cellular mechanisms.
6-Fluoromevalonate (CAS 2822-77-7) References
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- Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS/MS. | Henneman, L., et al. 2011. Biochim Biophys Acta. 1811: 227-33. PMID: 21237288
- Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability. | Kang, S., et al. 2015. Eur J Med Chem. 90: 448-61. PMID: 25461893
- De Novo Transcriptome and Expression Profile Analysis to Reveal Genes and Pathways Potentially Involved in Cantharidin Biosynthesis in the Blister Beetle Mylabris cichorii. | Huang, Y., et al. 2016. PLoS One. 11: e0146953. PMID: 26752526
- DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway. | Parrales, A., et al. 2016. Nat Cell Biol. 18: 1233-1243. PMID: 27775703
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- Drug repositioning of mevalonate pathway inhibitors as antitumor agents for ovarian cancer. | Kobayashi, Y., et al. 2017. Oncotarget. 8: 72147-72156. PMID: 29069775
- Genetic Adaptation of a Mevalonate Pathway Deficient Mutant in Staphylococcus aureus. | Reichert, S., et al. 2018. Front Microbiol. 9: 1539. PMID: 30050520
- Mechanisms of Trained Innate Immunity in oxLDL Primed Human Coronary Smooth Muscle Cells. | Schnack, L., et al. 2019. Front Immunol. 10: 13. PMID: 30728822
- Pyrvinium Pamoate Induces Death of Triple-Negative Breast Cancer Stem-Like Cells and Reduces Metastases through Effects on Lipid Anabolism. | Dattilo, R., et al. 2020. Cancer Res. 80: 4087-4102. PMID: 32718996
- High-throughput functional assay in cystic fibrosis patient-derived organoids allows drug repurposing. | Spelier, S., et al. 2023. ERJ Open Res. 9: PMID: 36726369
Inhibitor of:
MVD.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-Fluoromevalonate, 5 mg | sc-280541 | 5 mg | $235.00 | |||
6-Fluoromevalonate, 25 mg | sc-280541A | 25 mg | $810.00 |