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6-Fluoro-DL-tryptophan (CAS 7730-20-3)

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Alternate Names:
DL-2-Amino-3-(6-fluoroindolyl)propionic acid; H-6-Fluoro-DL-Trp-OH
Application:
6-Fluoro-DL-tryptophan is a serotonin (5-HT) synthesis inhibitor
CAS Number:
7730-20-3
Molecular Weight:
222.22
Molecular Formula:
C11H11FN2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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6-Fluoro-DL-tryptophan is a compound utilized in the field of chemical biology to probe the structure and dynamics of proteins. By introducing a fluorine atom into the tryptophan moiety, researchers can track the behavior of this modified amino acid using 19F NMR spectroscopy, which offers a high degree of sensitivity and specificity. This fluorinated derivative is particularly useful in studying the folding and function of proteins where tryptophan plays a critical role, as well as in understanding the intricacies of enzyme-substrate interactions. It is also employed in conformational studies of peptides and proteins, as the introduction of a fluorine atom can subtly alter the molecule′s bioactivity and stability, providing valuable data on the importance of tryptophan residues in biological systems. Additionally, 6-Fluoro-DL-tryptophan serves as a tool for investigating the mechanisms of action of tryptophan analogs in various metabolic pathways, offering a window into the complex processes of amino acid biosynthesis and degradation.


6-Fluoro-DL-tryptophan (CAS 7730-20-3) References

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  5. Expression of compstatin in Escherichia coli: incorporation of unnatural amino acids enhances its activity.  |  Katragadda, M. and Lambris, JD. 2006. Protein Expr Purif. 47: 289-95. PMID: 16406678
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

6-Fluoro-DL-tryptophan, 250 mg

sc-281490
250 mg
$105.00

6-Fluoro-DL-tryptophan, 500 mg

sc-281490A
500 mg
$202.00