6-Deoxy-6-fluoro-D-glucose (CAS 4536-08-7)

6-Deoxy-6-fluoro-D-glucose, a fluorinated glucose derivative, has emerged as a valuable tool in chemical biology research due to its unique properties and versatile applications. One prominent research area involves its utilization as a molecular probe for investigating glucose metabolism and transport processes in living systems. By incorporating a fluorine atom at the 6-position of the glucose molecule, this compound serves as a non-metabolizable analog of glucose, allowing researchers to trace the fate of glucose in biological systems using fluorine-19 nuclear magnetic resonance (NMR) spectroscopy. This technique enables real-time monitoring of glucose uptake, utilization, and metabolic flux in cells and tissues, offering insights into glucose homeostasis and metabolic dysregulation in various disease states, such as cancer, diabetes, and neurodegenerative disorders. Additionally, 6-Deoxy-6-fluoro-D-glucose has been employed in positron emission tomography (PET) imaging studies for non-invasive visualization and quantification of glucose uptake in vivo, facilitating the diagnosis and monitoring of metabolic diseases and cancer progression. Furthermore, its chemical reactivity has been harnessed in the synthesis of fluorinated carbohydrates and glycoconjugates, providing access to novel molecular probes and agents with improved stability and biological activity. Overall, 6-Deoxy-6-fluoro-D-glucose serves as a valuable tool in chemical biology research, enabling the elucidation of glucose-related metabolic pathways and the development of innovative diagnostic and strategies for various diseases.