Date published: 2025-10-16

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6-Cyclopropyl-1-methyl-1H-pyrazolo[3,4-b]pyridin-3-ylamine

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Molecular Weight:
188.23
Molecular Formula:
C10H12N4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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BIX01294 hydrochloride inhibits G9a. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. BIX01294 hydrochloride is a selective inhibitor of G9a HMTase (IC50 = 1.7 muM). It less effectively inhibits the HMTase G9a-like protein (GLP IC50 = 38 muM) and has no effect on other known HMTases. BIX01294 hydrochloride has been used in combination with the calcium channel activator BayK8644 to facilitate the generation of induced pluripotent stem cells from somatic cells in vitro. BIX01294 hydrochloride is an inhibitor of HDAC.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

6-Cyclopropyl-1-methyl-1H-pyrazolo[3,4-b]pyridin-3-ylamine, 500 mg

sc-325864
500 mg
$296.00

6-Cyclopropyl-1-methyl-1H-pyrazolo[3,4-b]pyridin-3-ylamine, 1 g

sc-325864A
1 g
$400.00