Date published: 2026-5-4

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6-Chloromethyl-pyridine-2-carboxylic acid methyl ester (CAS 220040-48-2)

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Alternate Names:
Methyl 6-(chloromethyl)picolinate
CAS Number:
220040-48-2
Molecular Weight:
185.61
Molecular Formula:
C8H8ClNO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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6-Chloromethyl-pyridine-2-carboxylic acid methyl ester is a synthetic organic compound. Its structure makes it an intermediate with valuable reactivity for the synthesis of a wide range of chemical products, including agrochemicals and various organic compounds. The presence of both a chloromethyl group and a methyl ester in the same molecule offers dual points of reactivity, allowing for the sequential or simultaneous introduction of different functional groups or molecular fragments. This can significantly streamline the synthesis of complex organic molecules, making it more efficient and cost-effective.The chloromethyl group (–CH2Cl) is a reactive functional group that can undergo nucleophilic substitution reactions. The methyl ester group (–COOCH3) can be easily converted into a range of other functional groups, such as carboxylic acids, alcohols, or amides.


6-Chloromethyl-pyridine-2-carboxylic acid methyl ester (CAS 220040-48-2) References

  1. Lanthanide complexes based on a diazapyridinophane platform containing picolinate pendants.  |  Roca-Sabio, A., et al. 2012. Inorg Chem. 51: 10893-903. PMID: 23016509
  2. Radiolabeling of HTE1PA: A new monopicolinate cyclam derivative for Cu-64 phenotypic imaging. In vitro and in vivo stability studies in mice.  |  Frindel, M., et al. 2014. Nucl Med Biol. 41 Suppl: e49-57. PMID: 24440584
  3. Monopicolinate cross-bridged cyclam combining very fast complexation with very high stability and inertness of its copper(II) complex.  |  Lima, LM., et al. 2014. Inorg Chem. 53: 5269-79. PMID: 24758339
  4. Optimizing the Readout of Lanthanide-DOTA Complexes for the Detection of Ligand-Bound Copper(I).  |  Hanna, JR., et al. 2017. Molecules. 22: PMID: 28505112
  5. Implementing f-Block Metal Ions in Medicine: Tuning the Size Selectivity of Expanded Macrocycles.  |  Thiele, NA., et al. 2019. Inorg Chem. 58: 10483-10500. PMID: 31246017

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

6-Chloromethyl-pyridine-2-carboxylic acid methyl ester, 1 g

sc-337163
1 g
$515.00