Molecular structure of 6-Chloro-1-hydroxybenzotriazole, CAS Number: 26198-19-6
6-Chloro-1-hydroxybenzotriazole (CAS 26198-19-6)
Alternate Names:
6-Chloro-1H-benzo[d][1,2,3]triazol-1-ol
Application:
6-Chloro-1-hydroxybenzotriazole is a reagent to suppress racemization
CAS Number:
26198-19-6
Molecular Weight:
169.57
Molecular Formula:
C6H4ClN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
6-Chloro-1-hydroxybenzotriazole is a reagent to suppress racemization in peptide coupling, which is not toxic. 6-Chloro-1-hydroxybenzotriazole (CHBT) is a highly researched small molecule with diverse applications across various fields. Its versatility makes it invaluable in both organic and inorganic chemistry. Acting as a intermediate in numerous synthetic processes, 6-Chloro-1-hydroxybenzotriazole finds utility in drug delivery, biocatalysis, and materials science.
6-Chloro-1-hydroxybenzotriazole (CAS 26198-19-6) References
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- Oxyma-B, an excellent racemization suppressor for peptide synthesis. | Jad, YE., et al. 2014. Org Biomol Chem. 12: 8379-85. PMID: 25233797
- Postsynthetic modification of unprotected peptides via S-tritylation reaction. | Mochizuki, M., et al. 2014. Org Lett. 16: 5740-3. PMID: 25322072
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- Efficient synthesis and characterisation of the amyloid beta peptide, Aβ1-42, using a double linker system. | Kasim, JK., et al. 2018. Org Biomol Chem. 17: 30-34. PMID: 30500032
- Expanding the Reaction Space of Linkage-Specific Sialic Acid Derivatization. | Pongracz, T., et al. 2019. Molecules. 24: PMID: 31597281
- Alanine scan-guided synthesis and biological evaluation of analogues of culicinin D, a potent anticancer peptaibol. | Kavianinia, I., et al. 2020. Bioorg Med Chem Lett. 30: 127135. PMID: 32229061
- N-[Chloro (dimethylamino) methylene]-N-methylmethanaminium chloride (TMUCl Cl), the reagent of choice for the solid-phase synthesis of anilides | Vendrell, M., Ventura, R., Ewenson, A., Royo, M., & Albericio, F. 2005. Tetrahedron letters. 46(32): 5383-5386.
- Convergent Solid-phase Peptide Synthesis Performed in a CHCl3-phenol Mixed Solvent: Synthesis of Amyloid β-peptides as Examples with a Difficult Sequence | Nishiuchi, Y., Nishio, H., Ishimaru, M., & Kimura, T. 2007. International Journal of Peptide Research and Therapeutics. 13(1-2): 119-128.
- Total synthesis of pseudacyclins A–E by an on-resin head-to-side chain concomitant cyclization-cleavage reaction | Bérubé, C., Borgia, A., & Voyer, N. 2018. Tetrahedron Letters. 59(47): 4176-4179.
- Efficient Fmoc group removal using diluted 4-methylpiperidine: an alternative for a less-polluting SPPS-Fmoc/tBu protocol | Rodríguez, V., Pineda, H., Ardila, N., Insuasty, D., Cárdenas, K., Román, J.,.. & García, J. 2020. International Journal of Peptide Research and Therapeutics. 26: 585-587.
- Denitrogenative cleavage of benzotriazoles and benzotriazinones, and selective N-desulfonylation of benzotriazoles by aluminum halides | Dong, B., Liu, Y., Yang, P., Sang, D., Tian, J., Li, L., & Long, S. 2022. Tetrahedron Letters. 103: 153965.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-Chloro-1-hydroxybenzotriazole, 25 g | sc-325799 | 25 g | $100.00 | |||
6-Chloro-1-hydroxybenzotriazole, 100 g | sc-325799A | 100 g | $128.00 | |||
6-Chloro-1-hydroxybenzotriazole, 500 g | sc-325799B | 500 g | $424.00 | |||
6-Chloro-1-hydroxybenzotriazole, 1 kg | sc-325799C | 1 kg | $740.00 |