Molecular structure of 6-Azauridine, CAS Number: 54-25-1
6-Azauridine (CAS 54-25-1)
Application:
6-Azauridine is can be applied in antiviral studies
CAS Number:
54-25-1
Molecular Weight:
245.19
Molecular Formula:
C8H11N3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
6-Azauridine is a compound of interest in biochemistry and molecular biology research due to its structural similarity to uridine, a natural nucleoside. It acts as a pyrimidine analog, which allows it to be incorporated into RNA molecules, thus providing a tool for studying RNA synthesis and function. The incorporation of 6-Azauridine into RNA strands can disrupt normal cellular processes, such as protein synthesis, and is therefore used to investigate the mechanisms of RNA-dependent cellular functions. Additionally, this compound is utilized in the study of nucleoside metabolism and nucleotide pool regulation. Researchers also explore its effects on the expression and regulation of genes, as 6-Azauridine can act as an antimetabolite, influencing the pathways that control the synthesis and breakdown of pyrimidine nucleotides.
6-Azauridine (CAS 54-25-1) References
- Paramyxovirus-avian cell relationship: discrepant impact of 6-azauridine on virus production by susceptible and less susceptible cells. | Saint Geme, JW., et al. 1975. Infect Immun. 11: 915-8. PMID: 1123255
- Interferon, ribavirin, 6-azauridine and glycyrrhizin: antiviral compounds active against pathogenic flaviviruses. | Crance, JM., et al. 2003. Antiviral Res. 58: 73-9. PMID: 12719009
- THE DEMONSTRATION OF THE SITE OF ACTION OF THE ANTIMETABOLITE DRUG 6-AZAURIDINE BY THE USE OF LEUCOCYTE CULTURES. | BUTTOO, AS., et al. 1964. Br J Pharmacol Chemother. 23: 90-2. PMID: 14206272
- Growth inhibition of tobacco tissue cultures with 6-azauracil, 6-azauridine and maleic hydrazide. | Schaeffer, GW. and Sorokin, T. 1966. Plant Physiol. 41: 971-5. PMID: 16656364
- Regioselectivity-reversal in acylation of 6-azauridine catalyzed by Burkholderia cepacia lipase. | Wang, ZY., et al. 2012. Biotechnol Lett. 34: 55-9. PMID: 21898129
- Resistance to pyrazofurin and 6-azauridine in normal MC3T3-E1 murine osteoblasts. | Beidler, DR., et al. 1989. Biochim Biophys Acta. 1014: 101-7. PMID: 2479415
- β-Cyanuryl Ribose, β-Barbituryl Ribose, and 6-Azauridine as Uridine Mimetics. | Salameh, H., et al. 2020. ACS Omega. 5: 31314-31322. PMID: 33324842
- 6-Azauridine Induces Autophagy-Mediated Cell Death via a p53- and AMPK-Dependent Pathway. | Cha, YE., et al. 2021. Int J Mol Sci. 22: PMID: 33799444
- In vitro sensitivity of measles virus to 6-azauridine. | Leonard, LL., et al. 1971. Proc Soc Exp Biol Med. 136: 857-62. PMID: 4995330
- Studies on 6-azauridine and 6-azacytidine. IV. Correlations between metabolism and central nervous effects of 6-azacytidine. | Janků, I., et al. 1965. Biochem Pharmacol. 14: 1545-8. PMID: 5867509
- Studies on 6-azauridine and 6-azacytidine. V. Influence of 6-azacytidine on prenatal development in mice. | Cerey, K., et al. 1965. Biochem Pharmacol. 14: 1549-56. PMID: 5893796
- In vivo synthesis of 6-azauridine 5'-triphosphate and incorporation of 6-azauridine into RNA of germinating wheat embryonic axes. | Rodaway, S. and Marcus, A. 1980. J Biol Chem. 255: 8402-4. PMID: 6157685
- Stimulation by 6-azauridine of carbamoyl phosphate synthesis for pyrimidine biosynthesis in mouse spleen slices. | Tatibana, M., et al. 1982. Eur J Biochem. 128: 625-9. PMID: 6185334
- Enhancement of intracellular 5-phosphoribosyl 1-pyrophosphate levels as a major factor in the 6-azauridine-induced stimulation of carbamoyl phosphate synthesis in mouse spleen slices. | Tatibana, M., et al. 1982. Eur J Biochem. 128: 631-6. PMID: 6185335
- 6-Azauridine, an inhibitor of the purine salvage pathway. | Partsch, G. and Eberl, R. 1977. Adv Exp Med Biol. 76B: 170-5. PMID: 855744
Inhibitor of:
γ Enolase, γ-GCSc, BDV, CTP Synthase (CTPS), DDX41, EXOSC (exosome component), GCN5, GlcAT-I, H6PD, MagT1, OMP, PBGD, PD-ECGF, RDH2, Rheb, TSEN34, UCKL1, UPase, and ZCCHC11.Activator of:
CTPS1, Imp4, and USP27X.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-Azauridine, 500 mg | sc-221082B | 500 mg | $97.00 | |||
6-Azauridine, 1 g | sc-221082 | 1 g | $159.00 | |||
6-Azauridine, 2 g | sc-221082C | 2 g | $295.00 | |||
6-Azauridine, 5 g | sc-221082A | 5 g | $679.00 |