(+)-6-Aminopenicillanic acid (CAS 551-16-6)

(+)-6-Aminopenicillanic acid is a pivotal compound in the field of antibiotic research, renowned for its role as the core structure of penicillin and various semi-synthetic penicillin derivatives. Its significance lies in its ability to serve as a substrate for enzymatic reactions leading to the synthesis of β-lactam antibiotics, which are highly effective against a broad spectrum of bacterial infections. Scientific investigations have delved deep into understanding the biosynthetic pathways involved in the production of penicillins, often utilizing (+)-6-Aminopenicillanic acid as a key starting material. Researchers have explaind the complex enzymatic mechanisms responsible for transforming this compound into diverse penicillin analogs, thus expanding the arsenal of antibiotics available to combat bacterial pathogens. Furthermore, (+)-6-Aminopenicillanic acid has been extensively employed in structural studies aimed at deciphering the interactions between β-lactam antibiotics and their target enzymes, notably penicillin-binding proteins (PBPs). By elucidating these molecular interactions at the atomic level, scientists gain crucial insights into antibiotic resistance mechanisms and develop strategies to overcome them.