Molecular structure of 6,2′-Dihydroxyflavone
6,2′-Dihydroxyflavone
Application:
6,2′-Dihydroxyflavone is is a partial inverse agonist at GABAA receptors with a-subunit selectivity
Molecular Weight:
254.24
Molecular Formula:
C15H10O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
This is a partial inverse agonist at GABAA receptors with a-subunit selectivity.
6,2′-Dihydroxyflavone References
- Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. | Huen, MS., et al. 2003. Biochem Pharmacol. 66: 2397-407. PMID: 14637197
- Microbial and enzymatic transformations of flavonoids. | Das, S. and Rosazza, JP. 2006. J Nat Prod. 69: 499-508. PMID: 16562863
- 6,2'-Dihydroxyflavone, a subtype-selective partial inverse agonist of GABAA receptor benzodiazepine site. | Wang, F., et al. 2007. Neuropharmacology. 53: 574-82. PMID: 17681556
- QSAR modeling of the interaction of flavonoids with GABA(A) receptor. | Duchowicz, PR., et al. 2008. Eur J Med Chem. 43: 1593-602. PMID: 18158201
- New hybrid genetic based Support Vector Regression as QSAR approach for analyzing flavonoids-GABA(A) complexes. | Goodarzi, M., et al. 2009. J Chem Inf Model. 49: 1475-85. PMID: 19492793
- Dual effects of crude extracts obtained from Petiveria alliacea L. (Phytolaccaceae) on experimental anxiety in mice. | Blainski, A., et al. 2010. J Ethnopharmacol. 128: 541-4. PMID: 20079419
- Flavonoid modulation of GABA(A) receptors. | Hanrahan, JR., et al. 2011. Br J Pharmacol. 163: 234-45. PMID: 21244373
- Effects of flavone 6-substitutions on GABAA receptors efficacy. | Ren, L., et al. 2011. Eur J Pharmacol. 670: 121-9. PMID: 21914441
- Flavones from Erythrina falcata are modulators of fear memory. | de Oliveira, DR., et al. 2014. BMC Complement Altern Med. 14: 288. PMID: 25096710
- Interactions of flavonoids with ionotropic GABA receptors. | Hanrahan, JR., et al. 2015. Adv Pharmacol. 72: 189-200. PMID: 25600371
- Analysis of polyphenols in Aegle marmelos leaf and ameliorative efficacy against diabetic mice through restoration of antioxidant and anti-inflammatory status. | Ibrahim, M., et al. 2022. J Food Biochem. 46: e13852. PMID: 34250628
- GABAA receptors: structure, function, pharmacology, and related disorders. | Ghit, A., et al. 2021. J Genet Eng Biotechnol. 19: 123. PMID: 34417930
Substrate of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6,2′-Dihydroxyflavone, 5 mg | sc-300048 | 5 mg | $119.00 |