Molecular structure of 5(S)-HPETE, CAS Number: 71774-08-8
5(S)-HPETE (CAS 71774-08-8)
Application:
5(S)-HPETE is a histamine release and calcium flux augmenter
CAS Number:
71774-08-8
Molecular Weight:
336.47
Molecular Formula:
C20H32O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid produced by 5-lipoxygenase metabolism of arachidonic acid and a biosynthetic precursor to leukotrienes. 5(S)-HPETE is described to induce c-fos without inducing c-jun in TA1 cells, suggesting that c-fos induction by TNF may be HPETE-mediated. 5(S)-HPETE is also described to modulate histamine release from human basophils.
5(S)-HPETE (CAS 71774-08-8) References
- 12-Lipoxygenase from rat basophilic leukemia cells, an oxygenase with leukotriene A4-synthase activity. | van der Donk, EM., et al. 1992. Biochim Biophys Acta. 1128: 14-25. PMID: 1390874
- TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite. | Haliday, EM., et al. 1991. EMBO J. 10: 109-15. PMID: 1899225
- ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid. | Smyrniotis, CJ., et al. 2014. Biochemistry. 53: 4407-19. PMID: 24893149
- 12-Lipoxygenase from bovine polymorphonuclear leukocytes, an enzyme with leukotriene A4-synthase activity. | Walstra, P., et al. 1987. Biochem Biophys Res Commun. 149: 258-65. PMID: 2825701
- Analysis of serum polyunsaturated fatty acid metabolites in allergic bronchopulmonary aspergillosis. | Li, L., et al. 2020. Respir Res. 21: 205. PMID: 32758241
- Purification, characterization, and structural properties of a single protein from rat basophilic leukemia (RBL-1) cells possessing 5-lipoxygenase and leukotriene A4 synthetase activities. | Hogaboom, GK., et al. 1986. Mol Pharmacol. 30: 510-9. PMID: 3785138
- Lipoxygenase products modulate histamine release in human basophils. | Peters, SP., et al. 1981. Nature. 292: 455-7. PMID: 6166867
- Mono- and dihydroxyeicosatetraenoic acids alter calcium homeostasis in rabbit neutrophils. | Naccache, PH., et al. 1981. J Clin Invest. 67: 1584-7. PMID: 6262382
- Evidence for a lipoxygenase mechanism in the biosynthesis of epoxide and dihydroxy leukotrienes from 15(S)-hydroperoxyicosatetraenoic acid by human platelets and porcine leukocytes. | Maas, RL. and Brash, AR. 1983. Proc Natl Acad Sci U S A. 80: 2884-8. PMID: 6304687
- Isolation of a lipid-soluble histamine release factor from human platelets. | Proudfoot, AE., et al. 1994. Biochem Biophys Res Commun. 201: 443-8. PMID: 7515234
- A revised structure for the disialosyl globo-series gangliosides of human erythrocytes and chicken skeletal muscle. | Levery, SB., et al. 1994. Arch Biochem Biophys. 312: 125-34. PMID: 8031119
- Specificity of two lipoxygenases from rice: unusual regiospecificity of a lipoxygenase isoenzyme. | Zhang, LY. and Hamberg, M. 1996. Lipids. 31: 803-9. PMID: 8869882
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5(S)-HPETE, 50 µg | sc-200962 | 50 µg | $275.00 | |||
5(S)-HPETE, 100 µg | sc-200962A | 100 µg | $335.00 |