Molecular structure of 5(S),6(R)-DiHETE, CAS Number: 82948-88-7
5(S),6(R)-DiHETE (CAS 82948-88-7)
Alternate Names:
(5S,6S)-DIHYDROXY-(7E,9E,11Z,14Z)-EICOSATETRAENOIC ACID
Application:
5(S),6(R)-DiHETE is a LTD4 receptor agonist
CAS Number:
82948-88-7
Molecular Weight:
336.50
Molecular Formula:
C20H32O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5(S),6(R)-DiHETE is an enzymatic metabolite of leukotriene A4 that functions as a CysLT1 Receptor (LTD4 (sc-201048) receptor) agonist. Studies show that the activation of the CysLT1 Receptor results in the contraction of lung parenchyma cells. In addition, it is the vicinal diol′s specific structure that is essential for binding to the CysLT1 Receptor since other stereoisomers of the agonist do not bind to the receptor. These contractions in lung parenchyma cells are readily inhibited by FPL 55712 (sc-203583).
5(S),6(R)-DiHETE (CAS 82948-88-7) References
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- Conversion of 5,6-dihydroxyeicosatetraenoic acids. A novel pathway for lipoxin formation by human platelets. | Tornhamre, S., et al. 1992. FEBS Lett. 304: 78-82. PMID: 1618303
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- Leukotriene A4 metabolites are endogenous ligands for the Ah receptor. | Chiaro, CR., et al. 2008. Biochemistry. 47: 8445-55. PMID: 18616291
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- Enzymatic formation of 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid: kinetics of the reaction and stereochemistry of the product. | Haeggström, J., et al. 1988. Biochim Biophys Acta. 958: 469-76. PMID: 2829972
- Leukotriene A4. Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase. | Haeggström, J., et al. 1986. J Biol Chem. 261: 6332-7. PMID: 3009453
- Subgingival Microbiome and Specialized Pro-Resolving Lipid Mediator Pathway Profiles Are Correlated in Periodontal Inflammation. | Lee, CT., et al. 2021. Front Immunol. 12: 691216. PMID: 34177951
- On the biosynthesis of specialized pro-resolving mediators in human neutrophils and the influence of cell integrity. | Mainka, M., et al. 2022. Biochim Biophys Acta Mol Cell Biol Lipids. 1867: 159093. PMID: 34942381
- Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds. | Borgeat, P. and Samuelsson, B. 1979. J Biol Chem. 254: 7865-9. PMID: 468794
- Comparative activity of natural mono-, di- and tri-hydroxy derivatives of arachidonic acid on guinea-pig lungs: myotropic effect and stimulation of cyclooxygenase activity. | Sirois, P., et al. 1982. Prostaglandins. 24: 405-18. PMID: 6296925
Activator of:
CysLT1 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5(S),6(R)-DiHETE, 50 µg | sc-200421 | 50 µg | $202.00 | |||
5(S),6(R)-DiHETE, 1 mg | sc-200421A | 1 mg | $2400.00 |