5(S),12(R)-DiHETE(6-trans-LTB4) (CAS 71652-82-9)
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Leukotrienes comprise a family of endogenous metabolites of certain fatty acids and are related to thromboxanes and prostaglandins. They are potent eicosanoid lipid mediators that play numerous roles in inflammation, immunological functions and maintaining biological homeostasis. Leukotrienes possess a conjugated triene structure which gives them their name. They are generally isolated from leukocytes and primarily act through specific G protein-coupled receptors. Biosynthesis of 5(S),12(R)-DiHETE(6-trans-LTB4) has been shown to occur via nonenzymatic and enzymatic hydrolysis of LTA4 and by myeloperoxidase-dependent metabolism of cysteinyl leukotrienes. Observations indicate that it is a neutrophil chemotaxin in guinea pig dermis and a metabolite of LTB4 in rat kidney produced enzymatically by a novel isomerase reaction.
5(S),12(R)-DiHETE(6-trans-LTB4) (CAS 71652-82-9) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5(S),12(R)-DiHETE(6-trans-LTB4), 50 µg | sc-200423 | 50 µg | $147.00 | |||
5(S),12(R)-DiHETE(6-trans-LTB4), 1 mg | sc-200423A | 1 mg | $2400.00 |