Molecular structure of 5′-N-Ethylcarboxamidoadenosine, CAS Number: 35920-39-9
5′-N-Ethylcarboxamidoadenosine (CAS 35920-39-9)
Alternate Names:
NECA; 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide
Application:
5′-N-Ethylcarboxamidoadenosine is a potent Adenosine A Receptor agonist
CAS Number:
35920-39-9
Purity:
≥98%
Molecular Weight:
308.29
Molecular Formula:
C12H16N6O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5′-N-Ethylcarboxamidoadenosine is a nucleoside analog that is widely used in biochemical and physiological research. As an adenosine receptor agonist, this compound is of interest for its role in the activation of adenosine receptors, which are implicated in various intracellular signaling pathways. Researchers utilize 5′-N-Ethylcarboxamidoadenosine to study the effects of adenosine receptor activation on cellular processes such as neurotransmission, inflammation, and immune responses. The compound is also valuable in the exploration of signal transduction mechanisms, particularly those involving cAMP as a secondary messenger. In addition, 5′-N-Ethylcarboxamidoadenosine is employed in the investigation of cardiovascular functions. Its impact on cell proliferation and apoptosis is another area of study, contributing to a broader understanding of cellular responses to external stimuli.
5′-N-Ethylcarboxamidoadenosine (CAS 35920-39-9) References
- Role of adenosine receptors in caffeine tolerance. | Holtzman, SG., et al. 1991. J Pharmacol Exp Ther. 256: 62-8. PMID: 1846425
- Effects of NG-nitro-L-arginine methyl ester on vasodilator responses to acetylcholine, 5'-N-ethylcarboxamidoadenosine or salbutamol in conscious rats. | Gardiner, SM., et al. 1991. Br J Pharmacol. 103: 1725-32. PMID: 1933136
- The adenosine analog, 5'-N-ethylcarboxamidoadenosine, exerts mixed agonist action on cardiorespiratory parameters in the intact but not decerebrate rat following microinjections into the nucleus tractus solitarius. | Barraco, RA., et al. 1990. Brain Res. 530: 54-72. PMID: 2271953
- Cardiorespiratory function is altered by picomole injections of 5'-N-ethylcarboxamidoadenosine into the nucleus tractus solitarius of rats. | Barraco, RA., et al. 1990. Brain Res. 507: 234-46. PMID: 2337763
- 5'-N-ethylcarboxamidoadenosine is not a paralog-specific Hsp90 inhibitor. | Liu, S. and Street, TO. 2016. Protein Sci. 25: 2209-2215. PMID: 27667530
- Roles of calcium and the endothelium in the relaxations produced by 5'-N-ethylcarboxamidoadenosine (NECA). | Sabouni, MH., et al. 1989. Eur J Pharmacol. 166: 311-4. PMID: 2792197
- Inherent hyporesponsiveness to methylxanthine-induced behavioral changes associated with supersensitivity to 5'-N-ethylcarboxamidoadenosine (NECA). | Seale, TW., et al. 1986. Pharmacol Biochem Behav. 25: 1271-7. PMID: 3809230
- Involvement of alpha-adrenoceptors in the excitatory effect of the A2 adenosine receptors agonist 5'-N-ethylcarboxamidoadenosine (NECA) on cardiac automaticity in the isolated right ventricle of the rat. | Hernández, J., et al. 1994. Naunyn Schmiedebergs Arch Pharmacol. 350: 632-7. PMID: 7708120
- The endothelium of the rat renal artery plays an obligatory role in A2 adenosine receptor-mediated relaxation induced by 5'-N-ethylcarboxamidoadenosine and N6-cyclopentyladenosine. | Martin, PL. and Potts, AA. 1994. J Pharmacol Exp Ther. 270: 893-9. PMID: 7932201
- 5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms. | Berg, KA., et al. 1994. Mol Pharmacol. 45: 826-36. PMID: 8190100
- Restraint stress potentiates analgesia induced by 5'-N-ethylcarboxamidoadenosine: comparison with morphine. | Woolfolk, DR. and Holtzman, SG. 1993. Eur J Pharmacol. 239: 177-82. PMID: 8223892
- Comparison of adenosine and muscarinic receptor-mediated effects on protein phosphatase inhibitor-1 activity in the heart. | Gupta, RC., et al. 1993. J Pharmacol Exp Ther. 266: 16-22. PMID: 8392548
- The effect of N6-cyclohexyladenosine and 5'-N-ethylcarboxamidoadenosine on body temperature in normothermic rabbits. | Matuszek, M. and Gagało, IT. 1996. Gen Pharmacol. 27: 467-9. PMID: 8723528
- The effects of 5'-N-ethylcarboxamidoadenosine on evoked release of [3H]serotonin in the rat nucleus tractus solitarius. | Helfman, CC., et al. 1996. Neurosci Lett. 213: 61-5. PMID: 8844713
- Prolonged exposure to 5'-N-ethylcarboxamidoadenosine (NECA) does not affect the adenosine A2A-mediated vasodilation in porcine coronary arteries. | Conti, A., et al. 1997. Pharmacol Res. 35: 123-8. PMID: 9175581
Activator of:
Adenosine A1-R, Adenosine A2A-R, and Adenosine A3-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5′-N-Ethylcarboxamidoadenosine, 10 mg | sc-291071 | 10 mg | $84.00 | |||
5′-N-Ethylcarboxamidoadenosine, 15 mg | sc-291071A | 15 mg | $161.00 | |||
5′-N-Ethylcarboxamidoadenosine, 50 mg | sc-291071B | 50 mg | $231.00 |