5′-Iodo-5′-deoxy Adenosine (CAS 4099-81-4)
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5′-Iodo-5′-deoxy Adenosine is a nucleoside analog investigated extensively in research. This altered version of the natural nucleoside adenosine replaces the hydroxyl group at the 5′ position with an iodine atom. This adjustment has been proven to heighten the anti-tumor capabilities of the compound, holding substantial promise for further scientific exploration.The compound has exhibited the ability to initiate apoptosis, a programmed cell demise process, in cancer cells by disrupting DNA synthesis and repair mechanisms.The operational principle of 5′-Iodo-5′-deoxy Adenosine hinges on its integration into DNA during replication. The iodine atom at the 5′ position introduces structural irregularities in the DNA, causing DNA impairment and triggering the cell′s programmed cell death pathways.
5′-Iodo-5′-deoxy Adenosine (CAS 4099-81-4) References
- Adenosine cyclic 3',5'-monophosphate dependent protein kinase: a new fluorescence displacement titration technique for characterizing the nucleotide binding site on the catalytic subunit. | Bhatnagar, D., et al. 1983. Biochemistry. 22: 6310-7. PMID: 6318814
- Effects of novel anti-viral adenosine analogues on the activity of S-adenosylhomocysteine hydrolase from human liver. | Fabianowska-Majewska, K., et al. 1994. Biochem Pharmacol. 48: 897-903. PMID: 8093102
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5′-Iodo-5′-deoxy Adenosine, 25 mg | sc-221058 | 25 mg | $312.00 |