Molecular structure of 5′-Fluoroindirubinoxime, CAS Number: 861214-33-7
5′-Fluoroindirubinoxime (CAS 861214-33-7)
Application:
5′-Fluoroindirubinoxime is an antiproliferative agent and an inhibitor of FLT3
CAS Number:
861214-33-7
Molecular Weight:
295.27
Molecular Formula:
C16H10FN3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
5′-Fluoroindirubinoxime is an antiproliferative agent and an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3). This compound has been shown to be selective for FMT3 against 6 other kinases including EGFR.
5′-Fluoroindirubinoxime (CAS 861214-33-7) References
- Antitumor activity of novel indirubin derivatives in rat tumor model. | Kim, SA., et al. 2007. Clin Cancer Res. 13: 253-9. PMID: 17200363
- Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs. | Krivogorsky, B., et al. 2008. Antimicrob Agents Chemother. 52: 4466-9. PMID: 18824607
- Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. | Choi, SJ., et al. 2010. Bioorg Med Chem Lett. 20: 2033-7. PMID: 20153646
- In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. | Lemieux, GA., et al. 2013. PLoS Biol. 11: e1001712. PMID: 24260022
Inhibitor of:
Flt-3/Flk-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5′-Fluoroindirubinoxime, 10 mg | sc-361086 | 10 mg | $155.00 | |||
5′-Fluoroindirubinoxime, 50 mg | sc-361086A | 50 mg | $620.00 |