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5β-Pregnane-3α,20α-diol (CAS 80-92-2)

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Alternate Names:
Pregnanediol
Application:
5β-Pregnane-3α,20α-diol is an inactive metabolite of progesterone
CAS Number:
80-92-2
Molecular Weight:
320.51
Molecular Formula:
C21H36O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5β-Pregnane-3α,20α-diol is involved in the regulation of cellular processes by acting as a modulator of gene expression. It functions as a ligand for certain nuclear receptors, influencing the transcription of specific genes involved in various biological pathways. 5β-Pregnane-3α,20α-Diol interacts with intracellular receptors, leading to the activation or repression of target genes, thereby impacting cellular functions. It modulates the activity of transcription factors, which in turn regulate the expression of genes involved in metabolism, development, and homeostasis. 5β-Pregnane-3α,20α-diol plays a role in the modulation of cellular signaling pathways, influencing the cellular response to various stimuli. Its interaction with nuclear receptors and transcription factors contributes to the fine-tuning of gene expression, ultimately affecting cellular processes and functions.


5β-Pregnane-3α,20α-diol (CAS 80-92-2) References

  1. The metabolism of progesterone by animal tissues in vitro. 3. Investigation of the products of metabolism after incubation of 5beta-pregnane-3alpha:20alpha-diol with rabbit-liver homogenate.  |  TAYLOR, W. 1956. Biochem J. 62: 332-5. PMID: 13293192
  2. The identification of pregnanediol in liquor amnii, bile and faeces.  |  KLOPPER, AI. and MACNAUGHTON, MC. 1959. J Endocrinol. 18: 319-25. PMID: 13664854
  3. 20alpha-Hydroxysteroid dehydrogenase and 3alpha-hydroxysteroid dehydrogenase in human fetal liver.  |  VILLEE, CA. and LORING, JM. 1963. Endocrinology. 72: 824-8. PMID: 13997296
  4. Urinary analysis of 16(5alpha)-androsten-3alpha-ol by gas chromatography/combustion/isotope ratio mass spectrometry: implications in anti-doping analysis.  |  Saudan, C., et al. 2004. J Chromatogr B Analyt Technol Biomed Life Sci. 810: 157-64. PMID: 15358320
  5. delta13C-values of endogenous urinary steroids.  |  Flenker, U., et al. 2008. Steroids. 73: 408-16. PMID: 18241901
  6. Formation of 3alpha-hydroxy-5beta-pregnan-20-one in the ovaries of catfish, Heteropneustes fossilis (Bloch).  |  Ungar, F. and Gunville, R. 1977. Gen Comp Endocrinol. 31: 53-9. PMID: 188720
  7. Impact of progesterone administration on doping test of endogenous steroids.  |  Wang, J., et al. 2014. Anal Bioanal Chem. 406: 6061-7. PMID: 25103527
  8. The use of gas chromatography-mass spectrometry/combustion/isotope ratio mass spectrometry to demonstrate progesterone treatment in bovines.  |  Janssens, G., et al. 2016. J Chromatogr A. 1449: 129-40. PMID: 27157423
  9. Effect of maternal intrahepatic cholestasis on fetal steroid metabolism.  |  Laatikainen, TJ., et al. 1974. J Clin Invest. 53: 1709-15. PMID: 4275337
  10. Enteric excretion of metabolites of steroid hormones in the human subject. IV. Isolation of 5-beta-pregnane-3-alpha, 20-alpha-diol from meconium.  |  Francis, FE. and Kinsella, RA. 1966. J Clin Endocrinol Metab. 26: 128-32. PMID: 5905912
  11. Urinary excretion of 5beta-pregnane-3alpha,20alpha,21-triol in human gestation.  |  Begue, RJ., et al. 1978. Biomed Mass Spectrom. 5: 184-7. PMID: 630058
  12. The identification of novel steroid N-acetylglucosaminides in the urine of pregnant women.  |  Meng, LJ., et al. 1996. J Steroid Biochem Mol Biol. 58: 585-98. PMID: 8918986
  13. Metabolism and excretion of oestradiol-17beta and progesterone in the Sumatran rhinoceros (Dicerorhinus sumatrensis).  |  Heistermann, M., et al. 1998. Anim Reprod Sci. 53: 157-72. PMID: 9835374

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5β-Pregnane-3α,20α-diol, 10 mg

sc-210427
10 mg
$312.00

5β-Pregnane-3α,20α-diol, 25 mg

sc-210427A
25 mg
$468.00

5β-Pregnane-3α,20α-diol, 50 mg

sc-210427B
50 mg
$750.00

5β-Pregnane-3α,20α-diol, 100 mg

sc-210427C
100 mg
$1290.00

5β-Pregnane-3α,20α-diol, 13 g

sc-210427D
13 g
$8670.00