Molecular structure of 5β-Dihydrocortisol, CAS Number: 1482-50-4
5β-Dihydrocortisol (CAS 1482-50-4)
Alternate Names:
(5β,11β)-11,17,21-Trihydroxypregnane-3,20-dione
CAS Number:
1482-50-4
Molecular Weight:
364.48
Molecular Formula:
C21H32O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
5β-Dihydrocortisol (DHC), also recognized as 5α-dihydrocortisol or 5α-pregnane-3α,11β,17α-triol-20-one, is a naturally occurring steroid hormone synthesized in the adrenal cortex. It acts as a precursor to cortisol, another vital hormone. Operating under the name 5β-Dihydrocortisol, this metabolically active steroid hormone assumes a significant role in numerous physiological processes. Notably, it participates in the regulation of glucose metabolism,
5β-Dihydrocortisol (CAS 1482-50-4) References
- Measurement of urinary free cortisol using the Acs:180 serum cortisol chemiluminescent immunoassay. | Kennedy, DM., et al. 2000. Ann Clin Biochem. 37 (Pt 4): 520-8. PMID: 10902870
- Incorporation and metabolism of cortisol in oocytes of tilapia (Oreochromis mossambicus). | Tagawa, M., et al. 2000. J Exp Zool. 287: 485-92. PMID: 11110162
- The quantification of endogenous steroids in bovine aqueous humour and vitreous humour using isotope dilution GC-NCI-MS. | Iqbal, Z., et al. 2001. J Pharm Biomed Anal. 24: 535-43. PMID: 11272309
- Determination of natural corticosteroids in urine samples from sportsmen. | Rivero-Marabé, JJ., et al. 2001. J Chromatogr B Biomed Sci Appl. 761: 77-84. PMID: 11585134
- Human hepatic cortisol reductase activities: enzymatic properties and substrate specificities of cytosolic cortisol delta 4-5 beta-reductase and dihydrocortisol-3 alpha-oxidoreductase(s). | Iyer, RB., et al. 1990. Steroids. 55: 495-500. PMID: 2075615
- Activities of aldo-keto reductase 1 enzymes on two inhaled corticosteroids: implications for the pharmacological effects of inhaled corticosteroids. | Jin, Y. 2011. Chem Biol Interact. 191: 234-8. PMID: 21276783
- 5β-Reduced steroids and human Δ(4)-3-ketosteroid 5β-reductase (AKR1D1). | Chen, M. and Penning, TM. 2014. Steroids. 83: 17-26. PMID: 24513054
- Spectroscopic evaluation of synthesized 5β-dihydrocortisol and 5β-dihydrocortisol acetate binding mechanism with human serum albumin and their role in anticancer activity. | Kallubai, M., et al. 2019. J Biomol Struct Dyn. 37: 623-640. PMID: 29375009
- Indomethacin and glucocorticoid metabolism in rat liver cytosol. | Penning, TM. 1986. Biochem Pharmacol. 35: 4203-9. PMID: 3466590
- Quantification of cortisol and its metabolites in human urine by LC-MSn: applications in clinical diagnosis and anti-doping control. | Arioli, F., et al. 2022. Anal Bioanal Chem. 414: 6841-6853. PMID: 35915250
- Potentiation of glucocorticoid activity by 5 beta-dihydrocortisol: its role in glaucoma. | Weinstein, BI., et al. 1983. Science. 222: 172-3. PMID: 6623065
- Purification and characterization of 3 alpha/beta-hydroxysteroid dehydrogenase from mature porcine testicular cytosol. | Nakajin, S., et al. 1994. J Steroid Biochem Mol Biol. 48: 249-56. PMID: 8142302
- Decreased 3 alpha-hydroxysteroid dehydrogenase activity in peripheral blood lymphocytes from patients with primary open angle glaucoma. | Weinstein, BI., et al. 1996. Exp Eye Res. 62: 39-45. PMID: 8674511
- Increased glucocorticoid activity in men with cardiovascular risk factors. | Walker, BR., et al. 1998. Hypertension. 31: 891-5. PMID: 9535410
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5β-Dihydrocortisol, 100 mg | sc-499307 | 100 mg | $300.00 |