5β-Cholanic acid-3α, 6β-Diol (CAS 668-49-5)
See product citations (1)
QUICK LINKS
5β-Cholanic acid-3α, 6β-Diol is involved in the regulation of cholesterol metabolism. It functions as a precursor in the synthesis of bile acids. 5β-Cholanic Acid-3α, 6β-Diol plays a role in the conversion of cholesterol into primary bile acids in the liver, contributing to the maintenance of cholesterol homeostasis. At the molecular level, 5β-Cholanic acid-3α, 6β-Diol interacts with enzymes involved in bile acid synthesis, modulating their activity and ultimately influencing the production of bile acids. Its mechanism of action involves the activation of specific metabolic pathways that lead to the conversion of cholesterol into bile acids, thereby contributing to the regulation of lipid metabolism. In experimental applications, this chemical′s function is to serve as a key intermediate in the biosynthesis of bile acids, playing a specific role in the metabolic processes related to cholesterol and lipid homeostasis.
5β-Cholanic acid-3α, 6β-Diol (CAS 668-49-5) References
- Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity. | Kitada, H., et al. 2003. J Biol Chem. 278: 17838-44. PMID: 12637555
- ME3738 protects against lithocholic acid-induced hepatotoxicity, which is associated with enhancement of biliary bile acid and cholesterol output. | Nomoto, M., et al. 2007. Eur J Pharmacol. 574: 192-200. PMID: 17651726
- Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed farnesoid X receptor (FXR)-null mice: FXR-independent suppression of intestinal bile acid absorption. | Miyata, M., et al. 2009. Drug Metab Dispos. 37: 338-44. PMID: 18988759
- Regulation of bile acid synthesis by fat-soluble vitamins A and D. | Schmidt, DR., et al. 2010. J Biol Chem. 285: 14486-94. PMID: 20233723
- Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method. | García-Cañaveras, JC., et al. 2012. J Lipid Res. 53: 2231-2241. PMID: 22822028
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5β-Cholanic acid-3α, 6β-Diol, 2 mg | sc-396743 | 2 mg | $141.00 |