Molecular structure of 5α-Cholestane, CAS Number: 481-21-0
5α-Cholestane (CAS 481-21-0)
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Application:
5α-Cholestane is a standard in cholesterol analysis by GC and HPLC, it is produced endogeneously in humans
CAS Number:
481-21-0
Molecular Weight:
372.67
Molecular Formula:
C27H48
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5α-Cholestane is a cycloalkane with a five-carbon ring structure and a side chain consisting of four carbon atoms. Its mode of action involves binding to and regulating the function of proteins related to cholesterol metabolism, inflammation, and cancer. Specifically, 5α-Cholestane has demonstrated the ability to bind to and regulate the enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), an important player in cholesterol metabolism.
5α-Cholestane (CAS 481-21-0) References
- An improved method for the capillary gas chromatographic derivatization of polyhydroxylated steroids having tert-hydroxyl groups. | Iida, T., et al. 2003. Anal Sci. 19: 1317-21. PMID: 14516087
- Faecal sterols determination in wastewater and surface water. | Gilli, G., et al. 2006. J Chromatogr B Analyt Technol Biomed Life Sci. 843: 120-4. PMID: 16787764
- Regioselective oxyfunctionalization of unactivated carbons in steroids by a model of cytochrome P-450: osmiumporphyrin complex/tert-butyl hydroperoxide system. | Iida, T., et al. 2007. J Org Chem. 72: 823-30. PMID: 17253801
- Manganese porphyrins catalyze selective C-H bond halogenations. | Liu, W. and Groves, JT. 2010. J Am Chem Soc. 132: 12847-9. PMID: 20806921
- Formation and inhibition of cholesterol oxidation products during marinating of pig feet. | Chen, YC., et al. 2012. J Agric Food Chem. 60: 173-9. PMID: 22117593
- Determination of total cholesterol in meat and poultry by gas chromatography: single-laboratory validation. | Dinh, TT., et al. 2012. J AOAC Int. 95: 472-88. PMID: 22649935
- Volatility of organic molecular markers used for source apportionment analysis: measurements and implications for atmospheric lifetime. | May, AA., et al. 2012. Environ Sci Technol. 46: 12435-44. PMID: 23013599
- Surface occupancy plays a major role in cholesterol's condensing effect. | Krause, MR., et al. 2013. Langmuir. 29: 10303-6. PMID: 23902525
- Direct Sampling and Analysis of Atmospheric Particulate Organic Matter by Proton-Transfer-Reaction Mass Spectrometry. | Müller, M., et al. 2017. Anal Chem. 89: 10889-10897. PMID: 28911223
- High-volume steroid isotopic standards developed as working standards for gas chromatography-combustion-isotope ratio mass spectrometry. | Tobias, HJ. and Brenna, JT. 2018. Drug Test Anal. 10: 781-785. PMID: 28960904
- Improved Analytical Method for Determination of Cholesterol-Oxidation Products in Meat and Animal Fat by QuEChERS Coupled with Gas Chromatography-Mass Spectrometry. | Chiu, CW., et al. 2018. J Agric Food Chem. 66: 3561-3571. PMID: 29526092
- Role of the cholesterol hydroxyl group in the chemical exchange saturation transfer signal at -1.6 ppm. | Chang, YC., et al. 2020. NMR Biomed. 33: e4356. PMID: 32575161
- Quantitative analysis of cholesterol in 5 to 20 microliter of plasma. | Ishikawa, TT., et al. 1974. J Lipid Res. 15: 286-91. PMID: 4827918
- A simplified method for the determination of steroids in diets and faeces. | Roseleur, OJ. and van Gent, CM. 1978. Clin Chim Acta. 82: 13-23. PMID: 618675
- GLC determination of aprindine: quantitation and stability measurement. | Rutherford, BS. and Bishara, RH. 1976. J Pharm Sci. 65: 1322-5. PMID: 966145
- New method for determination of fecal sterols in urine using non-chlorinated solvents. | Börjesson, E., et al. 1998. J Chromatogr B Biomed Sci Appl. 713: 438-42. PMID: 9746261
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FADS1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5α-Cholestane, 100 mg | sc-214348 | 100 mg | $92.00 | |||
5α-Cholestane, 1 g | sc-214348A | 1 g | $235.00 |