Date published: 2025-9-26

1-800-457-3801

SCBT Portrait Logo
Seach Input

5α-Androst-16-en-3-one (CAS 18339-16-7)

5.0(1)
Write a reviewAsk a question

See product citations (1)

Alternate Names:
16-(5α)Androsten-3-one, 3-Keto-5α,16-androstene; Androstenone
Application:
5α-Androst-16-en-3-one is a mammalian pheromone
CAS Number:
18339-16-7
Molecular Weight:
272.43
Molecular Formula:
C19H28O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

5α-Androst-16-en-3-one is a highly intriguing and complex compound belonging to the class of androgenic steroids, naturally occurring as a metabolite within the intricate biochemical pathways of steroidogenesis. This particular steroid is distinguished by its unique chemical structure, which plays a pivotal role in the study of chemical communication and signaling mechanisms within various biological systems. Its molecular configuration, characterized by a double bond at the 16th carbon position and a ketone group at the 3rd carbon, is critical for its interaction with specific receptors and enzymes, thus influencing a wide array of biochemical processes. Researchers have leveraged 5α-Androst-16-en-3-one as a tool to decipher the underlying mechanisms of pheromonal activity, especially in the context of animal behavior studies. The compound′s ability to modulate receptor activity and signal transduction pathways offers a window into understanding the chemical basis of communication in the animal kingdom. As such, 5α-Androst-16-en-3-one serves as a valuable chemical probe in the exploration of the molecular mechanisms driving these complex biological phenomena, aiding in the advancement of our knowledge in biochemistry and endocrinology.


5α-Androst-16-en-3-one (CAS 18339-16-7) References

  1. A radioimmunoassay for 5alpha-androst-16-en-3-one in porcine adipose tissue.  |  Andresen, O. 1975. Acta Endocrinol (Copenh). 79: 619-24. PMID: 1173512
  2. Binding of the pheromonal steroid, 5alpha-androst-16-en-3-one, to membrane-enriched fractions of boar and rat olfactory epithelium; preliminary evidence for binding protein being a glycoprotein.  |  Kraevskaya, MA., et al. 2003. J Steroid Biochem Mol Biol. 86: 133-41. PMID: 14568564
  3. Effect of 5alpha-androst-16-en-3-one on oxytocin release in oestrous sows.  |  Mattioli, M., et al. 1986. Theriogenology. 25: 399-403. PMID: 16726129
  4. Male subjects who could not perceive the pheromone 5a-androst-16-en-3-one, produced similar orbitofrontal changes on PET compared with perceptible phenylethyl alcohol (rose).  |  Treyer, V., et al. 2006. Rhinology. 44: 278-82. PMID: 17216746
  5. The suppressive effect of apricot kernel extract on 5alpha-Androst-16-en-3-one generated by microbial metabolism.  |  Mikoshiba, S., et al. 2006. Int J Cosmet Sci. 28: 45-52. PMID: 18492200
  6. An improved microtitre enzyme immunoassay to measure the boar taint steroid 5α-androst-16-en-3-one in blood plasma of pigs.  |  Claus, R., et al. 2008. Meat Sci. 80: 934-8. PMID: 22063620
  7. Development of an analytical approach for identification and quantification of 5-α-androst-16-en-3-one in human milk.  |  Hartmann, C., et al. 2013. Steroids. 78: 156-60. PMID: 23186599
  8. Responsiveness of human neonates to the odor of 5α-androst-16-en-3-one: a behavioral paradox?  |  Loos, HM., et al. 2014. Chem Senses. 39: 693-703. PMID: 25217699
  9. Changes of Androstenone Concentrations in Saliva of Boars with Age.  |  Pokorná, K., et al. 2022. Animals (Basel). 12: PMID: 35049780
  10. Olfactory perception of 5α-androst-16-en-3-one: Data obtained in the residents of central Russia.  |  Klyuchnikova, MA., et al. 2022. Data Brief. 45: 108704. PMID: 36426003
  11. Development of an enzyme immunoassay to measure urinary and faecal 5α-androst-16-en-3-one in pigs.  |  Kumar, V. and Umapathy, G. 2023. MethodsX. 10: 102178. PMID: 37122363
  12. Studies on the metabolism of 5alpha-androst-16-en-3-one in boar tests in vivo.  |  Saat, YA., et al. 1974. Biochem J. 144: 347-52. PMID: 4462588
  13. Studies on the receptors to 5alpha-androst-16-en-3-one and 5alpha-androst-16-en-3alpha-ol in sow nasal mucosa.  |  Gennings, JN., et al. 1977. Biochim Biophys Acta. 496: 547-56. PMID: 836907
  14. Enhanced sensitivity to androstenone following regular exposure to pemenone.  |  Stevens, DA. and O'Connell, RJ. 1995. Chem Senses. 20: 413-9. PMID: 8590026
  15. Use of gas chromatographic-mass spectrometric techniques in studies of androst-16-ene and androgen biosynthesis in human testis; cytosolic specific binding of 5alpha-androst-16-en-3-one.  |  Kwan, TK., et al. 1997. J Steroid Biochem Mol Biol. 60: 137-46. PMID: 9182868

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5α-Androst-16-en-3-one, 5 mg

sc-227030
5 mg
$66.00

5α-Androst-16-en-3-one, 50 mg

sc-227030A
50 mg
$260.00

my project is relative with this kind of hormone, so that company has ELISA kit to detect this one? Please reply my email. Thank you.

Asked by: thaodo
Thank you for your question. We do not sell ELISA kits for detection of this phermone, 5α-Androst-16-en-3-one (CAS 18339-16-7).
Answered by: Technical Support
Date published: 2017-09-20
  • y_2025, m_9, d_24, h_6CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_227030, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 111ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from KlyuchnikovaKlyuchnikova, MA. et al. (PubMed 24385176) investigated the effect of short-term exposure to the mammalian steroid 5 -Androst-16-en-3-one on the behavior and hormonal status in male mice. -SCBT Publication Review
Date published: 2015-04-17
  • y_2025, m_9, d_24, h_6
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_227030, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 16ms
  • REVIEWS, PRODUCT
5α-Androst-16-en-3-one is rated 5.0 out of 5 by 1.
  • y_2025, m_9, d_24, h_6
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_227030, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 111ms
  • REVIEWS, PRODUCT