5-trans Latanoprost
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Latanoprost is an F-series prostaglandin analog that has been approved for use as an ocular hypotensive drug(1). 5-trans Latanoprost is an isomer of latanoprost wherein the double bond between carbons 5 and 6 has been changed from cis (Z) to trans (E). The trans isomer of latanoprost occurs as an impurity of 2-5% in most commercial preparations of bulk drug product. The present compound was prepared as an analytical standard for detection and quantitation of this impurity. From what can be inferred from the study of other trans isomers of F-type prostaglandins, 5-trans latanoprost′s biological activity is similar to that of the cis isomer. However, there are no specific published reports on the biological activity, and on the intraocular hypotensive activity in particular, of 5-trans latanoprost.
5-trans Latanoprost References
1 Stjernschantz, J., Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs of the Future 17 691-704 (1992).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-trans Latanoprost, 1 mg | sc-223704 | 1 mg | $118.00 | |||
5-trans Latanoprost, 5 mg | sc-223704A | 5 mg | $399.00 |