5(S),6(S)-DiHETE (CAS 82948-87-6)

5(S),6(S)-DiHETE, assigned CAS number 82948-87-6, is a dihydroxy derivative of arachidonic acid, specifically formed through the enzymatic action of lipoxygenases. This compound is characterized by the addition of hydroxyl groups at both the 5th and 6th carbon positions in the arachidonic acid chain, a modification which significantly alters its bioactivity compared to its parent compound. In research, 5(S),6(S)-DiHETE is utilized as a tool to investigate the complex interactions and functions of lipid metabolites in cellular signaling networks. Its mechanisms of action involve modulating the activities of various key signaling pathways that regulate cellular processes such as proliferation, differentiation, and response to oxidative stress. By studying 5(S),6(S)-DiHETE, researchers gain insights into the role of dihydroxylated eicosanoids in cell biology, particularly their involvement in signaling cascades that influence cellular behavior in non-disease contexts. For example, studies involving this compound help to explain how cells adapt to changes in their environment through alterations in lipid signaling molecules. Additionally, this research contributes to a broader understanding of the physiological functions of lipid metabolites in various biological systems, thereby informing fields such as biochemistry, cellular biology, and systems biology.