5(S),6(R)-Lipoxin A4 methyl ester (CAS 97643-35-1)

5(S),6(R)-Lipoxin A4 methyl ester, with the CAS number 97643-35-1, is a chemically modified derivative of Lipoxin A4, a lipid mediator involved in the resolution of inflammation. This specific derivative features a methyl ester modification, which enhances its stability and alters its biological properties compared to its parent compound. The primary mechanism by which 5(S),6(R)-Lipoxin A4 methyl ester acts involves its interaction with specific cell surface receptors that are typically engaged by lipid mediators. This interaction can modulate various cellular pathways associated with inflammation, including the inhibition of leukocyte recruitment and the promotion of non-phlogistic phagocytosis by macrophages. In research, this compound has been utilized to study the extended effects and potential enhanced bioavailability provided by the methyl ester modification, particularly how these changes affect the molecule′s interaction with cellular receptors and subsequent signaling pathways. Studies focus on its role in synthetic pathways that mimic or influence natural anti-inflammatory processes, providing insights into the development of novel approaches for modulating inflammation without employing traditional methods. The insights gained from research involving 5(S),6(R)-Lipoxin A4 methyl ester are crucial for understanding the complex network of lipid mediators that govern the resolution phases of inflammatory responses.