5(S),6(R)-11-trans DiHETE

5(S),6(R)-11-trans DiHETE is a specialized metabolite derived from arachidonic acid, a polyunsaturated omega-6 fatty acid that is a common component of cellular membranes. This compound is part of the dihydroxyeicosatetraenoic acids (DiHETEs) family, which are produced through the action of lipoxygenase enzymes on arachidonic acid. Specifically, 5(S),6(R)-11-trans DiHETE is generated via the lipoxygenase pathway, which involves the insertion of oxygen at specific positions of the arachidonic acid molecule to form hydroperoxy intermediates that are subsequently reduced to hydroxides. In research, this chemical is particularly interesting for studying the complex interactions within the lipid signaling pathways that regulate various cellular processes such as inflammation, cell proliferation, and the response to cellular damage. Researchers use 5(S),6(R)-11-trans DiHETE to explore these pathways by examining its effects on different types of cells and tissues, and how it influences the production of other signaling molecules. Studies focus on its role in the modulation of signaling cascades that control cellular responses to external stimuli, providing insights into the complex network of lipid-based cellular communication. This research is crucial for understanding the fundamental mechanisms of cell biology and the broader implications of lipid mediators in health and disease dynamics.