Molecular structure of 5(S),15(S)-DiHETE, CAS Number: 82200-87-1
5(S),15(S)-DiHETE (CAS 82200-87-1)
Alternate Names:
5S,15S-dihydroxy-6E,8Z,10Z,13E-eicosatetraenoic acid
Application:
5(S),15(S)-DiHETE is an enhancer of neutrophil degranulation and potent chemotaxin
CAS Number:
82200-87-1
Purity:
99%
Molecular Weight:
336.5
Molecular Formula:
C20H32O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5(S),15(S)-DiHETE is a dihydroxy analog of arachidonic acid and is of significant interest in research focusing on lipid signaling and inflammation. This compound is mainly utilized in studies to understand its role in the metabolism of polyunsaturated fatty acids and the intricate pathways it participates in. 5(S),15(S)-DiHETE is often examined for its effects on various cell types, including its involvement in the modulation of immune responses by influencing leukocyte activity. In addition, it is a key subject in investigations related to its influence on vascular function and the resolution phase of inflammation. This compound′s interactions with other eicosanoids and its impact on cell signaling cascades provide valuable insights into the complex network of lipid mediators.
5(S),15(S)-DiHETE (CAS 82200-87-1) References
- Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes. | Powell, WS., et al. 1992. J Biol Chem. 267: 19233-41. PMID: 1326548
- Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis. | Bannenberg, GL., et al. 2004. J Exp Med. 199: 515-23. PMID: 14970178
- Transformations of 5-HETE by activated keratinocyte 15-lipoxygenase and the activation mechanism. | Green, FA. 1990. Lipids. 25: 618-23. PMID: 2127820
- Identification of a novel and highly potent eosinophil chemotactic lipid in human eosinophils treated with arachidonic acid. | Morita, E., et al. 1990. J Immunol. 144: 1893-900. PMID: 2155268
- Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators. | Dalli, J. and Serhan, CN. 2012. Blood. 120: e60-72. PMID: 22904297
- Alteration of leukotriene release by macrophages ingesting Toxoplasma gondii. | Locksley, RM., et al. 1985. Proc Natl Acad Sci U S A. 82: 6922-6. PMID: 2995993
- Gestational exposure to titanium dioxide, diesel exhaust, and concentrated urban air particles affects levels of specialized pro-resolving mediators in response to allergen in asthma-susceptible neonate lungs. | Kumar, M., et al. 2022. J Toxicol Environ Health A. 85: 243-261. PMID: 34802391
- On the biosynthesis of specialized pro-resolving mediators in human neutrophils and the influence of cell integrity. | Mainka, M., et al. 2022. Biochim Biophys Acta Mol Cell Biol Lipids. 1867: 159093. PMID: 34942381
- Formation of eicosanoids and other oxylipins in human macrophages. | Radmark, O. 2022. Biochem Pharmacol. 204: 115210. PMID: 35973581
- Effect of 15-lipoxygenase-derived arachidonate metabolites on human neutrophil degranulation. | O'Flaherty, JT. and Thomas, MJ. 1985. Prostaglandins Leukot Med. 17: 199-212. PMID: 3920680
- Formation of a novel dihydroxy acid from arachidonic acid by lipoxygenase-catalyzed double oxygenation in rat mononuclear cells and human leukocytes. | Maas, RL., et al. 1982. J Biol Chem. 257: 7056-67. PMID: 6806263
- Arachidonic acid 15-lipoxygenase products from human eosinophils. | Turk, J., et al. 1982. J Biol Chem. 257: 7068-76. PMID: 6806264
- 5(S),15(S)-dihydroxyeicosatetraenoic acid and lipoxin generation in human polymorphonuclear cells: dual specificity of 5-lipoxygenase towards endogenous and exogenous precursors. | Chavis, C., et al. 1996. J Exp Med. 183: 1633-43. PMID: 8666921
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5(S),15(S)-DiHETE, 50 µg | sc-200413 | 50 µg | $155.00 | |||
5(S),15(S)-DiHETE, 1 mg | sc-200413A | 1 mg | $2732.00 |