![5-Pyridin-3-yl-[1,3,4]thiadiazol-2-ylamine - chemical structure image](https://media.scbt.com/product/5-pyridin-3-yl-1-3-4thiadiazol-2-ylamine-structure_23_43_b_234316.jpg)
![5-Pyridin-3-yl-[1,3,4]thiadiazol-2-ylamine - chemical structure image](https://media.scbt.com/product/5-pyridin-3-yl-1-3-4thiadiazol-2-ylamine-structure_23_43_t_234316.jpg "Molecular structure of 5-Pyridin-3-yl-[1,3,4]thiadiazol-2-ylamine")
Molecular structure of 5-Pyridin-3-yl-[1,3,4]thiadiazol-2-ylamine
5-Pyridin-3-yl-[1,3,4]thiadiazol-2-ylamine
Molecular Weight:
178.21
Molecular Formula:
C7H6N4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Safety Information
SDS & Certificate of Analysis
AAL-993 is a highly potent inhibitor of Flt-1 (VEGFR-1), Flk-1 (VEGFR-2) and Flt-4 (VEGFR-3) (IC50=130nM, IC50=23nM and IC50=18nM respectively). At higher concentrations it inhibits PDGFR-beta (640nM), c-Kit (236nM) and c-Fms-CSF-1R (CSF-1R) (380nM). AAL-993 shows no activity towards other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl. An X-ray crystal structure of AAL-993 complexed with the catalytic domain of diphosphorylated VEGFR-2 indicates that this molecule binds to an inactive conformation of the protein.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Pyridin-3-yl-[1,3,4]thiadiazol-2-ylamine, 500 mg | sc-319054 | 500 mg | $248.00 |