Date published: 2026-2-2

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5-Phenyl-1,3,4-oxadiazole-2-thiol (CAS 3004-42-0)

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Alternate Names:
5-Phenyl-2-mercapto-1,3,4-oxadiazole
CAS Number:
3004-42-0
Molecular Weight:
178.21
Molecular Formula:
C8H6N2OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Phenyl-1,3,4-oxadiazole-2-thiol functions as a reactive intermediate in organic synthesis, participating in the formation of various compounds. It acts as a nucleophile in substitution reactions, allowing for the introduction of the phenyl-oxadiazole-thiol moiety into target molecules. 5-Phenyl-1,3,4-Oxadiazole-2-Thiol′s mechanism of action involves the attack of its sulfur atom on electrophilic centers of other molecules, leading to the formation of new carbon-sulfur bonds. This process enables the modification of organic compounds, contributing to the development of novel materials and substances.


5-Phenyl-1,3,4-oxadiazole-2-thiol (CAS 3004-42-0) References

  1. [Glycosylation of 5-Phenyl-1,3,4-oxadiazole-2-thiol with alpha-D-glucopyranosyl chloride under phase transfer conditions].  |  Kur'ianov, VO., et al. 2006. Bioorg Khim. 32: 520-3. PMID: 17042269
  2. 5,5'-Diphenyl-2,2'-[butane-1,4-diylbis(sulfanedi-yl)]bis-(1,3,4-oxadiazole).  |  Wang, W., et al. 2010. Acta Crystallogr Sect E Struct Rep Online. 66: o2931. PMID: 21589103
  3. Design, Synthesis and Evaluation of Novel 1-(Substituted Acetyl)-4-(10-Bromo-8-Chloro-5,6-Dihydro-11H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine-11-Ylidene)piperidines as Antitumor Agents and Farnesyl Protein Transferase Inhibitors.  |  Gatne, PS., et al. 2010. Indian J Pharm Sci. 72: 663-7. PMID: 21695007
  4. Tetra-aqua-bis-(2-{[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]sulfan-yl}acetato)-iron(II).  |  Wang, HR. and Li, GT. 2011. Acta Crystallogr Sect E Struct Rep Online. 67: m1457. PMID: 22058719
  5. Design and Synthesis of Novel N-Arylsulfonyl-3-(2-yl-ethanone)-6-methylindole Derivatives as Inhibitors of HIV-1 Replication.  |  Che, Z., et al. 2015. Pharmaceuticals (Basel). 8: 221-9. PMID: 26110320
  6. Utility of N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides as precursors for synthesis of new functionalized 1,3,4-thiadiazoles with potential antimicrobial activity.  |  Abdelhamid, AO., et al. 2015. J Adv Res. 6: 885-93. PMID: 26644926
  7. Novel gold(I) complexes with 5-phenyl-1,3,4-oxadiazole-2-thione and phosphine as potential anticancer and antileishmanial agents.  |  Chaves, JDS., et al. 2017. Eur J Med Chem. 127: 727-739. PMID: 27823888
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  10. Thiol-Reactive Bifunctional Chelators for the Creation of Site-Selectively Modified Radioimmunoconjugates with Improved Stability.  |  Adumeau, P., et al. 2018. Bioconjug Chem. 29: 1364-1372. PMID: 29509393
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Phenyl-1,3,4-oxadiazole-2-thiol, 5 g

sc-233438
5 g
$55.00