Molecular structure of TCS 1205, CAS Number: 355022-97-8
TCS 1205 (CAS 355022-97-8)
Alternate Names:
5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide
Application:
TCS 1205 is a GABAA α2 agonist
CAS Number:
355022-97-8
Purity:
≥97%
Molecular Weight:
337.33
Molecular Formula:
C18H15N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
GABAA α2 agonist and GABAA α1 partial agonist in vitro (Ki values are 14 and 121 nM respectively). Exhibits non-sedative anxiolytic activity in vivo.
TCS 1205 (CAS 355022-97-8) References
- [1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors. | Da Settimo, F., et al. 2001. J Med Chem. 44: 4359-69. PMID: 11728182
- Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor. | Taliani, S., et al. 2009. J Med Chem. 52: 3723-34. PMID: 19469479
- Anesthetics disrupt growth cone guidance cue sensing through actions on the GABAA α2 receptor mediated by the immature chloride gradient. | Xu, J., et al. 2019. Neurotoxicol Teratol. 74: 106812. PMID: 31251980
Activator of:
GABA Receptor, and GABAA R α 2.Substrate of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCS 1205, 10 mg | sc-358561 | 10 mg | $141.00 | |||
TCS 1205, 50 mg | sc-358561A | 50 mg | $619.00 |