5-Nitro-2-furoic acid (CAS 645-12-5)
QUICK LINKS
5-Nitro-2-furoic acid (5-NO2-FA) is a highly versatile organic compound extensively utilized in diverse scientific research applications. Derived from furan, it is a dicarboxylic acid. It presents as a white crystalline solid, displaying solubility in both water and organic solvents. The applications of 5-NO2-FA in scientific research are numerous and varied. Notably, it has been employed in the study of enzyme inhibitors, and as a corrosion inhibitor. As a starting material, it serves as a pivotal component for synthesizing various organic compounds, including 5-nitro-2-furoic acid esters and derivatives. Additionally, 5-Nitro-2-furoic acid finds utility in the synthesis of diverse nanomaterials, encompassing carbon nanotubes and graphene. Though the precise mechanism of action for 5-Nitro-2-furoic acid is not entirely elucidated, it has been found to effectively inhibit the activity of several enzymes, such as aldehyde dehydrogenase, xanthine oxidase, and cyclooxygenase.
5-Nitro-2-furoic acid (CAS 645-12-5) References
- Inhibition of T cell mitogenesis by nitrofurans. | Mercado, C., et al. 1991. Biochem Pharmacol. 41: 503-8. PMID: 1997001
- 5-Nitro-2-furoic acid hydrazones: design, synthesis and in vitro antimycobacterial evaluation against log and starved phase cultures. | Sriram, D., et al. 2010. Bioorg Med Chem Lett. 20: 4313-6. PMID: 20615698
- Synthesis of some new [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles starting from 5-nitro-2-furoic acid and evaluation of their antimicrobial activity. | Badr, SM. and Barwa, RM. 2011. Bioorg Med Chem. 19: 4506-12. PMID: 21723735
- Vibrational spectra, NBO analysis, first order hyperpolarizabilities, thermodynamic functions and NMR chemical shielding anisotropy (CSA) parameters of 5-nitro-2-furoic acid by ab initio HF and DFT calculations. | Balachandran, V., et al. 2013. Spectrochim Acta A Mol Biomol Spectrosc. 113: 268-80. PMID: 23735205
- Rational design of nitrofuran derivatives: Synthesis and valuation as inhibitors of Trypanosoma cruzi trypanothione reductase. | Arias, DG., et al. 2017. Eur J Med Chem. 125: 1088-1097. PMID: 27810595
- Hydrazide-hydrazones as potential antimicrobial agents: overview of the literature since 2010. | Popiołek, Ł. 2017. Med Chem Res. 26: 287-301. PMID: 28163562
- 5-Hydroxymethyl-Furfural and Structurally Related Compounds Block the Ion Conductance in Human Aquaporin-1 Channels and Slow Cancer Cell Migration and Invasion. | Chow, PH., et al. 2020. Mol Pharmacol. 98: 38-48. PMID: 32434851
- Oxoperoxovanadium Complexes of Hetero Ligands: X-Ray Crystal Structure, Density Functional Theory, and Investigations on DNA/BSA Interactions, Cytotoxic, and Molecular Docking Studies. | Kothandan, S., et al. 2022. Bioinorg Chem Appl. 2022: 8696420. PMID: 36034769
- Periphery Exploration around 2,6-Diazaspiro[3.4]octane Core Identifies a Potent Nitrofuran Antitubercular Lead. | Lukin, A., et al. 2023. Molecules. 28: PMID: 36985501
- Further Investigations of Nitroheterocyclic Compounds as Potential Antikinetoplastid Drug Candidates. | García-Estrada, C., et al. 2023. Biomolecules. 13: PMID: 37189384
- The mechanism of oxidative denitration of 5-nitrouracil and 5-nitro-2-furoic acid by hydroxyl radicals. | Zemel, H. and Neta, P. 1973. Radiat Res. 55: 393-8. PMID: 4743239
- Synthesis and antimicrobial activity of triorganotin 5-nitro-2-furoates. | Kupchik, EJ., et al. 1982. J Pharm Sci. 71: 311-4. PMID: 7069587
- Mutagenic activity of carcinogenic and noncarcinogenic nitrofurans and of urine of rats fed these compounds. | Wang, CY. and Lee, LH. 1976. Chem Biol Interact. 15: 69-75. PMID: 786488
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Nitro-2-furoic acid, 5 g | sc-239067 | 5 g | $50.00 |