Molecular structure of 5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB), CAS Number: 107254-86-4
5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB) (CAS 107254-86-4)
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Alternate Names:
NPPB
Application:
5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB) is a Cox inhibitor and GPR35 activator
CAS Number:
107254-86-4
Purity:
≥98%
Molecular Weight:
300.31
Molecular Formula:
C16H16N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB) (5-NPA) exists as a colorless crystalline solid, readily soluble in water and other polar solvents. The utilization of 5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB) spans a broad range of scientific research endeavors. In in vitro studies, its effects on enzymes, proteins, and other biological molecules have been scrutinized. While the precise mechanism of action of 5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB) is still being unravelled, current understanding suggests that it acts as an inhibitor of the enzyme acetylcholinesterase. This particular enzyme plays a vital role in the breakdown of the neurotransmitter acetylcholine. By inhibiting acetylcholinesterase, 5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB) leads to an accumulation of acetylcholine in the synaptic cleft.
5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB) (CAS 107254-86-4) References
- Localised fibre cell swelling characteristic of diabetic cataract can be induced in normal rat lens using the chloride channel blocker 5-nitro-2-(3-phenylpropylamino) benzoic acid. | Tunstall, MJ., et al. 1999. Ophthalmic Res. 31: 317-20. PMID: 10325548
- Properties of Ca(2+) release-activated Ca(2+) channel block by 5-nitro-2-(3-phenylpropylamino)-benzoic acid in Jurkat cells. | Li, JH., et al. 2000. Eur J Pharmacol. 394: 171-9. PMID: 10771282
- [Effects of monocarboxylic acid derivatives on cardiac ventricular CFTR Cl- channels in guinea pig]. | Zhou, SS. and Zang, YM. 1999. Sheng Li Xue Bao. 51: 297-302. PMID: 11498992
- Effects of 5-nitro-2-(3-phenylpropylamino) benzoic acid, anthracene-9-carboxylate, and zaprinast on endothelin-1-induced contractions of pregnant rat myometrium. | Kaya, T., et al. 2002. Eur J Obstet Gynecol Reprod Biol. 105: 114-9. PMID: 12381471
- Effects of NPPB (5-nitro-2-(3-phenylpropylamino)benzoic acid) on chloride transport in intestinal tissues and the T84 cell line. | Keeling, DJ., et al. 1991. Biochim Biophys Acta. 1115: 42-8. PMID: 1720331
- Increased hyperalgesia by 5-nitro-2, 3-(phenylpropylamino)-benzoic acid (NPPB), a chloride channel blocker in crush injury-induced neuropathic pain in rats. | Ramteke, VD., et al. 2009. Pharmacol Biochem Behav. 91: 417-22. PMID: 18775743
- 5-Nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist. | Taniguchi, Y., et al. 2008. Pharmacology. 82: 245-9. PMID: 18818509
- Cl(-)-channel blockers in the thick ascending limb of the loop of Henle. Structure activity relationship. | Wangemann, P., et al. 1986. Pflugers Arch. 407 Suppl 2: S128-41. PMID: 2434915
- Block of ATP-binding cassette B19 ion channel activity by 5-nitro-2-(3-phenylpropylamino)-benzoic acid impairs polar auxin transport and root gravitropism. | Cho, M., et al. 2014. Plant Physiol. 166: 2091-9. PMID: 25324509
- Inhibition of prostaglandin E2 synthesis by a blocker of epithelial chloride channels. | Breuer, W. and Skorecki, KL. 1989. Biochem Biophys Res Commun. 163: 398-405. PMID: 2549993
- Blocking kinetics of Cl- channels in colonic carcinoma cells (HT29) as revealed by 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB). | Dreinhöfer, J., et al. 1988. Biochim Biophys Acta. 946: 135-42. PMID: 2850000
- 5‑Nitro‑2‑(3‑phenylpropylamino) benzoic acid induces apoptosis of human lens epithelial cells via reactive oxygen species and endoplasmic reticulum stress through the mitochondrial apoptosis pathway. | Niu, L., et al. 2021. Int J Mol Med. 47: PMID: 33604681
- Investigation of the effects of 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) on membrane currents in rat portal vein. | Kirkup, AJ., et al. 1996. Br J Pharmacol. 117: 175-83. PMID: 8825360
- Cyclic AMP-dependent regulation of K+ transport in the rat distal colon. | Diener, M., et al. 1996. Br J Pharmacol. 118: 1477-87. PMID: 8832075
Inhibitor of:
band 3, Barttin, Bestrophin (BEST), Bestrophin-2, CLC-2, CLC-KB, CLCA2, CLCA5_Clac5, Clca6, CLIC1, Cox, LRRC8A, LRRC8D, NHE-2, NPT1, SLC26A7, SLC4A (Solute carrier family 4), TMEM14A, and TMEM16A.Activator of:
CLC-3, and GPR35.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB), 10 mg | sc-201542 | 10 mg | $109.00 | |||
5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB), 25 mg | sc-201542B | 25 mg | $193.00 | |||
5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB), 50 mg | sc-201542A | 50 mg | $317.00 |