Date published: 2026-5-7

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5-Methylmellein (CAS 7734-92-1)

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Alternate Names:
5- Methylochracin
Application:
5-Methylmellein is a widespread fungal pentaketide with weak antibacterial, antifungal and antiviral activity
CAS Number:
7734-92-1
Molecular Weight:
192.21
Molecular Formula:
C11H12O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Methylmellein is a dihydroisocoumarin derivative primarily used in chemical and biological research to study its biosynthesis and biological activity. Its mechanism of action involves functioning as a secondary metabolite produced by various fungi and plants, playing a role in their defense mechanisms. In research, 5-methylmellein has been utilized to investigate its biosynthetic pathways, particularly focusing on the enzymes and genes involved in its production. These studies often employ advanced techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry to explain its structure and quantify its presence in biological samples. Additionally, 5-methylmellein serves as a model compound in studies exploring the ecological roles of fungal metabolites, including their antimicrobial and allelopathic effects. Researchers have also examined its potential as a bioindicator for environmental monitoring due to its production in response to specific stress conditions. Recent applications include using 5-methylmellein in studies of plant-fungal interactions, where it is analyzed for its role in modulating plant defense responses. Its involvement in natural product research underscores its importance in understanding secondary metabolism and its ecological implications. This compound continues to be a valuable tool in both chemical and biological research, providing insights into natural product biosynthesis and its functional roles in nature.


5-Methylmellein (CAS 7734-92-1) References

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  2. Metabolites from the fungus Cephalosporium sp. AL031.  |  Bi, YM., et al. 2007. Arch Pharm Res. 30: 267-9. PMID: 17424929
  3. [Determination of multiple constituents in Wuling capsules by HPLC simultaneously].  |  Chen, Y., et al. 2012. Zhongguo Zhong Yao Za Zhi. 37: 218-21. PMID: 22737854
  4. Epoxynemanione A, nemanifuranones A-F, and nemanilactones A-C, from Nemania serpens, an endophytic fungus isolated from Riesling grapevines.  |  Ibrahim, A., et al. 2017. Phytochemistry. 140: 16-26. PMID: 28441516
  5. Preparation, characterization and cytotoxic evaluation of bovine serum albumin nanoparticles encapsulating 5-methylmellein: A secondary metabolite isolated from Xylaria psidii.  |  Arora, D., et al. 2017. Bioorg Med Chem Lett. 27: 5126-5130. PMID: 29100800
  6. 5-Methylmellein is a novel inhibitor of fungal sirtuin and modulates fungal secondary metabolite production.  |  Shigemoto, R., et al. 2018. J Gen Appl Microbiol. 64: 240-247. PMID: 29794367
  7. Characterization of a Bio-sourced, Fluorescent, Ratiometric pH Indicator with Alkaline pKa.  |  Alheety, S., et al. 2020. Photochem Photobiol. 96: 1176-1181. PMID: 32562274
  8. Characterization and Toxicity of Crude Toxins Produced by Cordyceps fumosorosea against Bemisia tabaci (Gennadius) and Aphis craccivora (Koch).  |  Wu, J., et al. 2021. Toxins (Basel). 13: PMID: 33803611
  9. [Secondary metabolites of endophyte Hypoxylon sp. HD-2014 from Uncaria rhynchophylla].  |  Yu, YH., et al. 2022. Zhongguo Zhong Yao Za Zhi. 47: 3816-3821. PMID: 35850839
  10. Antimicrobial metabolites produced by endophytic fungi associated with the leaves of Vochysia divergens.  |  Souza, JAM., et al. 2024. Nat Prod Res. 38: 978-985. PMID: 37154616

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Methylmellein, 1 mg

sc-396565
1 mg
$93.00

5-Methylmellein, 5 mg

sc-396565A
5 mg
$373.00