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5-Methylbenz[a]anthracene (CAS 2319-96-2)
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5-Methylbenz[a]anthracene is a compound utilized in research to study the process of chemical carcinogenesis. As a methylated analog of benz[a]anthracene, it provides insights into the mutagenic potential of polycyclic aromatic hydrocarbons (PAHs) and their interactions with cellular macromolecules. Its role in the induction of enzyme systems involved in the metabolism of xenobiotic compounds is of particular interest in toxicology. In environmental chemistry, 5-Methylbenz[a]anthracene serves as a marker for the presence of PAHs in ecosystems, aiding in the monitoring of pollution and its effects on wildlife. The compound′s behavior in organic matrices helps to model the environmental fate of similar contaminants. In the field of molecular biology, it is used to examine the mechanisms by which PAHs may induce genetic mutations, providing a framework for understanding the molecular basis of PAH-related carcinogenesis.
5-Methylbenz[a]anthracene (CAS 2319-96-2) References
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- Photoirradiation of polycyclic aromatic hydrocarbons with UVA light - a pathway leading to the generation of reactive oxygen species, lipid peroxidation, and dna damage. | Yu, H., et al. 2006. Int J Environ Res Public Health. 3: 348-54. PMID: 17159277
- UVA photoirradiation of oxygenated benz[a]anthracene and 3-methylcholanthene--generation of singlet oxygen and induction of lipid peroxidation. | Yin, JJ., et al. 2008. Int J Environ Res Public Health. 5: 26-31. PMID: 18441402
- Phototoxicity and environmental transformation of polycyclic aromatic hydrocarbons (PAHs)-light-induced reactive oxygen species, lipid peroxidation, and DNA damage. | Fu, PP., et al. 2012. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 30: 1-41. PMID: 22458855
- Genetic control of the regulation of cell susceptibility to carcinogenic polycyclic hydrocarbons by cyclic AMP. | Huberman, E., et al. 1974. Int J Cancer. 14: 789-98. PMID: 4377007
- Comparative carcinogenic activity of dimethyl and trimethyl derivatives of benz(a)anthracene in Fischer line 344 rats. | Dunning, WF., et al. 1968. Proc Soc Exp Biol Med. 128: 720-2. PMID: 5668115
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Methylbenz[a]anthracene, 25 mg | sc-482897 | 25 mg | $453.00 |