Molecular structure of 5-Methyl-2′-deoxycytidine, CAS Number: 838-07-3
5-Methyl-2′-deoxycytidine (CAS 838-07-3)
See product citations (11)
Alternate Names:
5-Methyl-2′-deoxycytidine is also known as 5-Methyl-dC.
Application:
5-Methyl-2′-deoxycytidine is a pyrimidine nucleoside isostere of thymidine, and analog of cytidine.
CAS Number:
838-07-3
Purity:
≥98%
Molecular Weight:
241.20
Molecular Formula:
C10H15N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-Methyl-2′-deoxycytidine is a pyrimidine nucleoside used in epigenetics research. In single stranded DNA, 5-Methyl-2′-deoxycytidine can act to signal de novo DNA methylation. 5-Methyl-2′-deoxycytidine is a cytidine (sc-221450) analog and an isostere of thymidine (sc-296542). 5-Methyl-2′-deoxycytidine is also used to investigate the connection between gene expression control and DNA methylation patterns.
5-Methyl-2′-deoxycytidine (CAS 838-07-3) References
- Formation of 5-formyl-2'-deoxycytidine from 5-methyl-2'-deoxycytidine in duplex DNA by Fenton-type reactions and gamma-irradiation. | Murata-Kamiya, N., et al. 1999. Nucleic Acids Res. 27: 4385-90. PMID: 10536146
- High-performance liquid chromatography determination of 5-methyl-2'-deoxycytidine, 2'-deoxycytidine, and other deoxynucleosides and nucleosides in DNA digests. | Magaña, AA., et al. 2008. Anal Biochem. 374: 378-85. PMID: 18157934
- HPCE quantification of 5-methyl-2'-deoxycytidine in genomic DNA: methodological optimization for chestnut and other woody species. | Hasbún, R., et al. 2008. Plant Physiol Biochem. 46: 815-22. PMID: 18538578
- Determination of 5-methyl-2'-deoxycytidine in genomic DNA using high performance liquid chromatography-ultraviolet detection. | Sandhu, J., et al. 2009. J Chromatogr B Analyt Technol Biomed Life Sci. 877: 1957-61. PMID: 19501556
- Direct analysis of 5-methylcytosine and 5-methyl-2'-deoxycytidine in human urine by isotope dilution LC-MS/MS: correlations with N-methylated purines and oxidized DNA lesions. | Hu, CW., et al. 2012. Chem Res Toxicol. 25: 462-70. PMID: 22268645
- Evaluation of 5-methyl-2'-deoxycytidine stability in hydrolyzed and nonhydrolyzed DNA by HPLC-UV. | Kovatsi, L., et al. 2012. Bioanalysis. 4: 367-72. PMID: 22394137
- The cyclobutane dimers of 2'-deoxyuridine, 2'-deoxycytidine, 5-methyl-2'-deoxycytidine and 5-bromo-2'-deoxyuridine. | Shetlar, MD. and Chung, J. 2012. Photochem Photobiol. 88: 1236-47. PMID: 22571327
- Potent methyl oxidation of 5-methyl-2'-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism. | Shao, J., et al. 2013. Free Radic Biol Med. 60: 177-82. PMID: 23376470
- Detection of oxidation products of 5-methyl-2'-deoxycytidine in Arabidopsis DNA. | Liu, S., et al. 2013. PLoS One. 8: e84620. PMID: 24391970
- Quantification of 5-methyl-2'-deoxycytidine in the DNA. | Giel-Pietraszuk, M., et al. 2015. Acta Biochim Pol. 62: 281-6. PMID: 26098716
- Simultaneous quantitative determination of 5-aza-2'-deoxycytidine genomic incorporation and DNA demethylation by liquid chromatography tandem mass spectrometry as exposure-response measures of nucleoside analog DNA methyltransferase inhibitors. | Anders, NM., et al. 2016. J Chromatogr B Analyt Technol Biomed Life Sci. 1022: 38-45. PMID: 27082761
- 5-Methyl-2'-deoxycytidine. Metabolism and effects on cell lethality studied with human leukemic cells in vitro. | Jekunen, A. and Vilpo, JA. 1984. Mol Pharmacol. 25: 431-5. PMID: 6587184
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Methyl-2′-deoxycytidine, 100 mg | sc-278256 | 100 mg | $80.00 | |||
5-Methyl-2′-deoxycytidine, 1 g | sc-278256A | 1 g | $161.00 | |||
5-Methyl-2′-deoxycytidine, 5 g | sc-278256B | 5 g | $338.00 | |||
5-Methyl-2′-deoxycytidine, 25 g | sc-278256C | 25 g | $1498.00 |