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5-Methoxytryptamine (CAS 608-07-1)

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Alternate Names:
3-(2-Aminoethyl)-5-methoxyindole; O-Methylserotonin
Application:
5-Methoxytryptamine is a nonselective serotonin receptor agonist
CAS Number:
608-07-1
Purity:
≥98%
Molecular Weight:
190.24
Molecular Formula:
C11H14N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Methoxytryptamine, also recognized for its role within the realm of serotonin receptor modulation, functions predominantly as a nonselective serotonin receptor agonist, excluding its interaction with the 5-HT3 receptor. This compound is distinguished by its capacity to mimic serotonin′s natural effects across various serotonin receptor subtypes, thereby playing a role in modulating neurotransmission processes. The specificity of 5-Methoxytryptamine in avoiding the 5-HT3 receptor highlights its unique interaction profile, offering useful for researchers aiming to dissect the intricate web of serotonin′s physiological and biochemical pathways. Through its widespread engagement with multiple serotonin receptors, 5-Methoxytryptamine facilitates the exploration of serotonin′s extensive role in neurotransmitter dynamics, providing insights into the underlying mechanisms of serotonin receptor activation and signal transduction. Its application in research applications extends to the study of serotonin′s influence on neural networks, contributing to a deeper understanding of its multifaceted roles in modulating neuronal function and behavior.


5-Methoxytryptamine (CAS 608-07-1) References

  1. 5-Hydroxytryptamine(7) receptor activation decreases slow afterhyperpolarization amplitude in CA3 hippocampal pyramidal cells.  |  Bacon, WL. and Beck, SG. 2000. J Pharmacol Exp Ther. 294: 672-9. PMID: 10900247
  2. Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.  |  Yu, AM., et al. 2003. Pharmacogenetics. 13: 173-81. PMID: 12618595
  3. Fourier transform infrared spectra and molecular structure of 5-methoxytryptamine, N-acetyl-5-methoxytryptamine and N-phenylsulfonamide-5-methoxytryptamine.  |  Bayari, S. and Ide, S. 2003. Spectrochim Acta A Mol Biomol Spectrosc. 59: 1255-63. PMID: 12659894
  4. 5-Methoxytryptamine is metabolized by monoamine oxidase A in the pineal gland and plasma of golden hamsters.  |  Raynaud, F. and Pévet, P. 1991. Neurosci Lett. 123: 172-4. PMID: 2027530
  5. Dose-related effects of prenatal 5-methoxytryptamine (5-MT) on development of serotonin terminal density and behavior.  |  Shemer, AV., et al. 1991. Brain Res Dev Brain Res. 59: 59-63. PMID: 2040080
  6. Plasma concentrations of 5-methoxytryptamine, 5-methoxytryptophol and melatonin after 5-methoxytryptamine administration of golden hamsters: physiological implications.  |  Raynaud, F., et al. 1991. J Neural Transm Gen Sect. 84: 33-43. PMID: 2054148
  7. 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum.  |  Craig, DA., et al. 1990. Naunyn Schmiedebergs Arch Pharmacol. 342: 9-16. PMID: 2402303
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  9. In vivo formation of 5-methoxytryptamine from melatonin in rat.  |  Beck, O. and Jonsson, G. 1981. J Neurochem. 36: 2013-8. PMID: 6940950
  10. Effect of 5-methoxytryptophan and 5-methoxytryptamine on the reproductive system of the male golden hamster.  |  Pévet, P., et al. 1981. J Neural Transm. 51: 303-11. PMID: 6945393
  11. 5-Methoxytryptamine inhibits cyclic AMP accumulation in cultured retinal neurons through activation of a pertussis toxin-sensitive site distinct from the 2-[125I]iodomelatonin binding site.  |  Iuvone, PM., et al. 1995. J Neurochem. 64: 1892-5. PMID: 7891120
  12. Functional characterization of 5-HT1D autoreceptors on the modulation of 5-HT release in guinea-pig mesencephalic raphe, hippocampus and frontal cortex.  |  el Mansari, M. and Blier, P. 1996. Br J Pharmacol. 118: 681-9. PMID: 8762094
  13. Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor.  |  Yamada, J., et al. 1997. Eur J Pharmacol. 323: 235-40. PMID: 9128844
  14. Participation of a cholinergic mechanism in 5-hydroxytryptamine (5-HT)3 and 5-HT4 receptor-mediated stimulation of gastric emptying in rats.  |  Yamano, M., et al. 1997. Arzneimittelforschung. 47: 1242-6. PMID: 9428982
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Methoxytryptamine, 1 g

sc-325556
1 g
$78.00

5-Methoxytryptamine, 5 g

sc-325556A
5 g
$233.00