5-Methoxymethyl-4-phenyl-2H-pyrazol-3-ylamine hydrochloride
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MK-2 Inhibitor III is a cell-permeable pyrrolopyridinyl compound that acts as a potent, selective, and ATP-biniding site-targeting MK-2/MAPKAP-K2 inhibitor (IC50 = 8.5, 81, and 210 nM agaisnt MAPKAPK-2 (MK-2), PRAK(MK-5), and 3pK(MK-3), respectively), while exhibiting much less or no activity against 8 other studied kinases. The inhibition of MK-2 presents a strategic approach to controlling the production of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-8. MK-2 Inhibitor III provides insights into how modulation of the p38 MAPK pathway can influence cell function and survival, particularly in the immune system and in cells exposed to environmental stressors.Shown to suppress LPS-induced TNF-alpha production in U937 cells (IC50 = 4.4 muM).
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Methoxymethyl-4-phenyl-2H-pyrazol-3-ylamine hydrochloride, 500 mg | sc-325550 | 500 mg | $285.00 |