Date published: 2025-10-15

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5-Methoxycarbonyl Methyl Uridine (CAS 29428-50-0)

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Alternate Names:
5-Carboxymethyluridine Methyl Ester
CAS Number:
29428-50-0
Molecular Weight:
316.26
Molecular Formula:
C12H16N2O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Methoxycarbonyl Methyl Uridine (5-MCMU) is a chemically modified nucleoside, distinguished by the presence of a methoxycarbonyl group attached to the methyl group at the 5′ position of uridine. This structural modification endows 5-Methoxycarbonyl Methyl Uridine with unique properties, notably its incorporation into RNA molecules during the transcription process. In research applications, 5-Methoxycarbonyl Methyl Uridine serves as a pivotal tool for probing RNA function and dynamics, allowing scientists to trace RNA molecules′ pathways and interactions within cellular environments. Its utility extends to the study of RNA metabolism and the mechanisms of RNA-based regulation, offering insights into the complex web of nucleic acid interactions that underpin cellular function. By enabling precise modifications of RNA structures, 5-Methoxycarbonyl Methyl Uridine aids in elucidating the roles of specific RNA modifications in various biological processes, thereby contributing to a deeper understanding of genetic regulation and the molecular machinery of life.


5-Methoxycarbonyl Methyl Uridine (CAS 29428-50-0) References

  1. Sulfur transfer and activation by ubiquitin-like modifier system Uba4•Urm1 link protein urmylation and tRNA thiolation in yeast.  |  Jüdes, A., et al. 2016. Microb Cell. 3: 554-564. PMID: 28357324
  2. A mutated dph3 gene causes sensitivity of Schizosaccharomyces pombe cells to cytotoxic agents.  |  Villahermosa, D., et al. 2017. Curr Genet. 63: 1081-1091. PMID: 28555368
  3. tRNA Modification: Is Cancer Having a Wobble?  |  Rapino, F., et al. 2017. Trends Cancer. 3: 249-252. PMID: 28718436
  4. METTL8 mRNA Methyltransferase Enhances Cancer Cell Migration via Direct Binding to ARID1A.  |  Lee, SA., et al. 2021. Int J Mol Sci. 22: PMID: 34063990
  5. Cysteine tRNAs of plant origin as novel UGA suppressors.  |  Urban, C. and Beier, H. 1995. Nucleic Acids Res. 23: 4591-7. PMID: 8524647
  6. Chapter 6 Three Dimensional Dynamic Structure of Transfer Rna by Nuclear Magnetic Resonance Spectroscopy  |  PF Agris, H Sierzputowska-Gracz. 1990. Journal of Chromatography Library. 45, Part A: A225-A253.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Methoxycarbonyl Methyl Uridine, 10 mg

sc-482751
10 mg
$390.00