5-Methoxybenzimidazole (CAS 4887-80-3)
QUICK LINKS
5-Methoxybenzimidazole is a chemical compound that functions as a nucleoside analog. It acts as an inhibitor of certain enzymes involved in nucleic acid synthesis, targeting the activity of DNA polymerase. 5-Methoxybenzimidazole disrupts the replication of genetic material by interfering with the polymerization process, ultimately leading to the inhibition of DNA synthesis. By binding to the active site of the enzyme, 5-Methoxybenzimidazole competes with the substrate, preventing the elongation of the DNA chain. This disruption of nucleic acid synthesis can be utilized in experimental applications to study the mechanisms of DNA replication and to investigate potential targets for antiviral or anticancer development. 5-Methoxybenzimidazole′s mechanism of action as a nucleoside analog provides insights into the molecular interactions involved in DNA polymerase activity, contributing to the understanding of nucleic acid biochemistry.
5-Methoxybenzimidazole (CAS 4887-80-3) References
- On the biosynthesis of 5-methoxybenzimidazole. Precursor-function of 5-hydroxybenzimidazole, benzimidazole and riboflavin. | Wurm, R., et al. 1975. Eur J Biochem. 56: 427-32. PMID: 1175633
- The corrinoid cofactor of reductive dehalogenases affects dechlorination rates and extents in organohalide-respiring Dehalococcoides mccartyi. | Yan, J., et al. 2016. ISME J. 10: 1092-101. PMID: 26555247
- Selective Utilization of Benzimidazolyl-Norcobamides as Cofactors by the Tetrachloroethene Reductive Dehalogenase of Sulfurospirillum multivorans. | Keller, S., et al. 2018. J Bacteriol. 200: PMID: 29378885
- Editorial: control of acid secretion. | Sachs, G., et al. 2018. Aliment Pharmacol Ther. 48: 682-683. PMID: 30132940
- Guided cobamide biosynthesis for heterologous production of reductive dehalogenases. | Schubert, T., et al. 2019. Microb Biotechnol. 12: 346-359. PMID: 30549216
- A New Class of Phosphoribosyltransferases Involved in Cobamide Biosynthesis Is Found in Methanogenic Archaea and Cyanobacteria. | Jeter, VL., et al. 2019. Biochemistry. 58: 951-964. PMID: 30640434
- CobT and BzaC catalyze the regiospecific activation and methylation of the 5-hydroxybenzimidazole lower ligand in anaerobic cobamide biosynthesis. | Mathur, Y., et al. 2020. J Biol Chem. 295: 10522-10534. PMID: 32503839
- Heterodimeric GW7604 Derivatives: Modification of the Pharmacological Profile by Additional Interactions at the Coactivator Binding Site. | Knox, AK., et al. 2021. J Med Chem. 64: 5766-5786. PMID: 33904307
- Accelerated microdroplet synthesis of benzimidazoles by nucleophilic addition to protonated carboxylic acids. | Basuri, P., et al. 2020. Chem Sci. 11: 12686-12694. PMID: 34094463
- Synthesis and Structure-Activity Relationships of Novel Non-Steroidal CYP17A1 Inhibitors as Potential Prostate Cancer Agents. | Wróbel, TM., et al. 2022. Biomolecules. 12: PMID: 35204665
- Combined read- and assembly-based metagenomics to reconstruct a Dehalococcoides mccartyi genome from PCB-contaminated sediments and evaluate functional differences among organohalide-respiring consortia in the presence of different halogenated contaminants. | Ewald, JM., et al. 2022. FEMS Microbiol Ecol. 98: PMID: 35665806
- Acinetobacter baumannii Catabolizes Ethanolamine in the Absence of a Metabolosome and Converts Cobinamide into Adenosylated Cobamides. | Villa, EA. and Escalante-Semerena, JC. 2022. mBio. 13: e0179322. PMID: 35880884
- Bioprocess Strategies for Vitamin B12 Production by Microbial Fermentation and Its Market Applications. | Calvillo, Á., et al. 2022. Bioengineering (Basel). 9: PMID: 36004890
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Methoxybenzimidazole, 5 g | sc-233391 | 5 g | $70.00 |