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Dynamin Inhibitor II is a cell-permeable cationic surfactant that reversibly inhibits Dynamin I GTPase activity (IC50 = 3.15 muM) by targeting the PH domain and interfering with phospholipid binding. Dynamin Inhibitor II may act to block Dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and Dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP. Dynamin Inhibitor II is an inhibitor of Dynamin II.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Isobutyl-4-morpholin-4-ylmethyl-furan-2-carboxylic acid, 500 mg | sc-318824 | 500 mg | $260.00 |